Relationship Between Mean Corpuscular Volume and Cognitive Performance in Older Adults

被引：29

作者：

Gamaldo, Alyssa A. ^{[1
]}

Ferrucci, Luigi ^{[2
]}

Rifkind, Joseph ^{[3
]}

Longo, Dan L. ^{[4
]}

Zonderman, Alan B. ^{[1
]}

机构：

[1] NIA, Lab Behav Neurosci, Baltimore, MD 21224 USA

[2] NIA, Clin Res Branch, Baltimore, MD 21224 USA

[3] NIA, Mol Dynam Sect, Baltimore, MD 21224 USA

[4] NIA, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2013年 / 61卷 / 01期

基金：

美国国家卫生研究院;

关键词：

mean corpuscular volume; cognition; older adults; MEMORY PERFORMANCE; OXIDATIVE STRESS; ANEMIA; PREVALENCE; YOUNG;

D O I：

10.1111/jgs.12066

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time. Design Longitudinal. Setting Sample from the Baltimore Longitudinal Study of Aging (BLSA). Participants Eight hundred twenty-seven participants from the BLSA (mean age 67, range 5096). Measurements Mean corpuscular volume and several other blood indices were measured, including hemoglobin, iron, ferritin, vitamin B12, folate, white blood cell count, albumin, and erythrocyte sedimentation rate. Cognitive performance was examined using neuropsychological measures of visual memory, verbal memory, language, attention, executive function, and global mental status. Results High MCV levels were significantly associated with lower global mental status even after adjusting for potential confounders. High MCV levels were also significantly associated with high rates of decline on tasks of global mental status, long delay memory, and attention, even after adjusting for potential confounders. Conclusion The findings confirm a previous observation that larger erythrocytes in older adults are associated with poorer cognitive function. Anemia and inflammation do not appear to explain the relationship between MCV and cognition. Further research is needed to clarify the mechanisms behind this association. J Am Geriatr Soc 61:84-89, 2013.

引用

页码：84 / 89

页数：6