In Vitro Antifungal Activity of Isavuconazole against Madurella mycetomatis

被引：38

作者：

Kloezen, Wendy ^{[1
]}

Meis, Jacques F. ^{[2
,3
]}

Curfs-Breuker, Ilse ^{[2
]}

Fahal, Ahmed H. ^{[4
]}

van de Sandea, Wendy W. J. ^{[1
]}

机构：

[1] Erasmus MC, Univ Med Ctr Rotterdam, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[2] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands

[4] Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 11期

关键词：

FRAGMENT LENGTH POLYMORPHISM; MODIFIED NCCLS METHOD; HYDROXIDE XTT ASSAY; ASPERGILLUS-FLAVUS; TRIAZOLE BAL4815; DOSE PHARMACOKINETICS; HEALTHY-VOLUNTEERS; SUSCEPTIBILITY; BAL8557; PRODRUG;

D O I：

10.1128/AAC.01170-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, with MICs ranging from <= 0.016 to 0.125 mu g/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma.

引用

页码：6054 / 6056

页数：3

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