Surfaces with instant and persistent antimicrobial efficacy against bacteria and SARS-CoV-2

被引：8

作者：

Dhyani, Abhishek ^{[1
,2
]}

Repetto, Taylor ^{[2
,3
]}

Bartikofsky, Dylan ^{[4
]}

Mirabelli, Carmen ^{[4
,9
]}

Gao, Zhihe ^{[1
,2
]}

Snyder, Sarah A. ^{[2
,3
]}

Snyder, Catherin ^{[2
,3
]}

Mehta, Geeta ^{[1
,3
,7
]}

Wobus, Christiane E. ^{[4
]}

VanEpp, J. Scott ^{[1
,2
,6
,7
,8
]}

Tuteja, Anish ^{[1
,2
,3
,5
]}

机构：

[1] Univ Michigan, Macromol Sci & Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA

[9] Univ Lubeck, Inst Virol & Cell Biol, D-23562 Lubeck, Germany

来源：

MATTER | 2022年 / 5卷 / 11期

关键词：

ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; SILVER; COPPER; MECHANISMS; RESISTANCE; METAL; NANOPARTICLES; DISINFECTION; TRANSMISSION;

D O I：

10.1016/j.matt.2022.08.018

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Surfaces contaminated with bacteria and viruses contribute to the transmission of infectious diseases and pose a significant threat to global public health. Modern day disinfection either relies on fast-acting (>3-log reduction within a few minutes), yet impermanent, liquid-, vapor-, or radiation-based disinfection techniques, or long-lasting, but slower-acting, passive antimicrobial surfaces based on heavy metal surfaces, or metallic nanoparticles. There is currently no surface that provides instant and persistent antimicrobial efficacy against a broad spectrum of bacteria and viruses. In this work, we describe a class of extremely durable antimicrobial surfaces incorporating different plant secondary metabolites that are capable of rapid disinfection (>4-log reduction) of current and emerging pathogens within minutes, while maintaining persistent efficacy over several months and under significant environmental duress. We also show that these surfaces can be readily applied onto a variety of desired substrates or devices via simple application techniques such as spray, flow, or brush coating. © 2022 Elsevier Inc.

引用

页码：4076 / +

页数：17

共 57 条

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