Isolation and Characterization of Tirandamycins from a Marine-Derived Streptomyces sp.

被引：68
|
作者：
Carlson, Jacob C.
Li, Shengying
Burr, Douglas A.
Sherman, David H. [1 ]
机构：
[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 11期
关键词：
RNA-POLYMERASE; MYXOCOCCUS-XANTHUS; BETA-SUBUNIT; STREPTOLYDIGIN; ACID; BIOSYNTHESIS; METABOLITES; INHIBITION; GENES;
D O I：
10.1021/np9005597
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The novel dienoyl tetramic acids tirandamycin C (1) and tirandamycin D (2) with activity against vancomycin-resistant Enterococcus faecalis were isolated from the marine environmental isolate Streptomyces sp. 307-9, which also produces the previously identified compounds tirandamycins A (3) and B (4). Spectroscopic analysis of 1 and 2 indicated structural similarity to 3 and 4, with differences only in the pattern of pendant oxygenation on the bicyclic ketal system. The isolation of these putative biosynthetic intermediates was enabled by their sequestration on an adsorbent resin during early stationary-phase fermentation.
引用
收藏
页码：2076 / 2079
页数：4
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