Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection

被引：12

作者：

Matsunaga, Yasuka ^{[1
]}

Clark, Trevon ^{[1
]}

Wanek, Alanna G. ^{[1
]}

Bitoun, Jacob P. ^{[2
]}

Gong, Qingqing ^{[3
]}

Good, Misty ^{[3
]}

Kolls, Jay K. ^{[1
]}

机构：

[1] Tulane Sch Med, Ctr Translat Res Infect & Inflammat, New Orleans, LA 70112 USA

[2] Tulane Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA

[3] Washington Univ, Dept Pediat, St Louis, MO 63110 USA

来源：

JOURNAL OF IMMUNOLOGY | 2021年 / 206卷 / 04期

关键词：

MUCOSAL IMMUNITY; HOST PROTECTION; HELPER-CELLS; INNATE; MICROBIOTA; BACTERIA; RECEPTOR; EPITHELIUM; RESPONSES; DEFENSE;

D O I：

10.4049/jimmunol.2000591

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 17 cytokines have been strongly implicated in mucosal immunity, in part by regulating the production of antimicrobial peptides. Using a mouse model of Citrobacter rodentium infection, which causes colitis, we found that intestinal IL-17RA and IL-17RC were partially required for control of infection in the colon and IL-17 regulates the production of luminal hydrogen peroxide as well as expression of Tnsf13. Reduced Tnfsf13 expression was associated with a profound defect in generating C. rodentium-specific IgA(+) Ab-secreting cells. Taken together, intestinal IL-17R signaling plays key roles in controlling invading pathogens, in part by regulating luminal hydrogen peroxide as well as regulating the generation of pathogen-specific IgA(+) Ab-secreting cells.

引用

页码：766 / 775

页数：10

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