The effect of Delphinium denudatum (Jadwar) on fatigue: A randomized double blind placebo-controlled clinical trial

Objectives: Fatigue is a common problem in modern-day life. The aim of this study was to evaluate the effect of Delphinium denudatum (Jadwar) on fatigue. Methods: This study was a randomized double-blind placebo-controlled clinical trial between healthy normal university students. In each group, participants were given one capsule of either WEACURE (R) (containing 500 mg of Jadwar root powder) or placebo for 15 consecutive days. Multidimensional Fatigue Inventory (MFI) questionnaire was used before and after the intervention to evaluate different aspects of fatigue. Results: A total number of 64 participants completed the study. Data analysis showed decrease in the scores of all five domains of fatigue in Jadwar group (13.31 +/- 3.05-7.75 +/- 2.66, 12.31 +/- 3.55-7.63 +/- 2.62, 12.22 +/- 4.26-6.97 +/- 2.06, 11.56 +/- 4.21 to 7.28 +/- 2.37, 12.91 +/- 3.09-7.34 +/- 2.13 in general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue domains, respectively) which was statistically significant (P value < 0.0001). This situation was significantly superior to the placebo group. Prescribed dosage of WEACURE (R) capsule was well tolerated. Conclusion: As a complementary tonic agent, Jadwar have a potential to reduce fatigue in normal population. However, objective evaluation of its anti-fatigue effect should be further evaluated.