Complete genome sequence of a virulent Newcastle disease virus isolated from an outbreak in chickens in Egypt

被引:25
|
作者
Mohamed, Mahmoud H. A. [1 ,2 ]
Kumar, Sachin [1 ]
Paldurai, Anandan [1 ]
Megahed, Mohamed M. [2 ]
Ghanem, Ibrahim A. [2 ]
Lebdah, Mohamed A. [2 ]
Samal, Siba K. [1 ]
机构
[1] Univ Maryland, Virginia Maryland Reg Coll Vet Med, College Pk, MD 20742 USA
[2] Zagazig Univ, Fac Vet Med, Zagazig, Egypt
关键词
Newcastle disease virus; African strain; Complete genome sequence; Phylogenetic analysis; FUSION PROTEIN; CLEAVAGE; STRAINS; MUTANTS; TRAILER; AFRICA;
D O I
10.1007/s11262-009-0385-7
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The complete genome sequence of a virulent Newcastle disease virus (NDV) isolated from chickens in Egypt was determined and compared to the sequence of NDV strains isolated from different parts of the world. The genome is 15,186 nucleotides (nt) long and consists of 6 genes in the order of 3'-N-P-M-F-HN-L-5'. The genome contains a 55-nt leader region at the 3' end and a 114-nt trailer region at the 5' end. Interestingly, the phylogenetic analysis showed that strain Egypt is closely related with the NDV strains isolated in China. In addition, the sequence of the fusion protein cleavage site of strain Egypt was identical to that of the NDV strain recently isolated in Mali. Determination of complete genome sequences of additional NDV strains from Africa is necessary to understand the epidemiology of currently circulating viruses in Africa.
引用
收藏
页码:234 / 237
页数:4
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