Prognostic Subcellular Notch2, Notch3 and Jagged1 Localization Patterns in Early Triple-negative Breast Cancer

被引：14

作者：

Strati, Titika-Marina ^{[1
]}

Kotoula, Vassiliki ^{[2
,3
]}

Kostopoulos, Ioannis ^{[2
]}

Manousou, Kyriaki ^{[4
]}

Papadimitriou, Christos ^{[5
]}

Lazaridis, Georgios ^{[6
]}

Lakis, Sotiris ^{[3
]}

Pentheroudakis, George ^{[7
]}

Pectasides, Dimitrios ^{[8
]}

Pazarli, Elissavet ^{[9
]}

Christodoulou, Christos ^{[10
]}

Razis, Evangelia ^{[11
]}

Pavlakis, Kitty ^{[12
]}

Magkou, Christina ^{[13
]}

Chrisafi, Sofia ^{[3
]}

Aravantinos, Gerasimos ^{[14
]}

Bafaloukos, Dimitrios ^{[15
]}

Papakostas, Pavlos ^{[16
]}

Gogas, Helen ^{[17
]}

Kalogeras, Konstantine T. ^{[3
,18
]}

Fountzilas, George ^{[3
,19
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Surg 3, Sch Hlth Sci,Fac Med, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Sch Hlth Sci, Fac Med, Dept Pathol, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Hellen Fdn Canc Res, Mol Oncol Lab, Thessaloniki, Greece

[4] Hellen Cooperat Oncol Grp, Data Off, Biostat Sect, Athens, Greece

[5] Univ Athens, Sch Med, Alexandra Hosp, Dept Clin Therapeut, Athens, Greece

[6] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Dept Med Oncol, Sch Hlth Sci,Fac Med, Thessaloniki, Greece

[7] Ioannina Univ Hosp, Ioannina, Greece

[8] Hippokrateion Hosp, Dept Internal Med 2, Oncol Sect, Athens, Greece

[9] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Dept Pathol, Sch Hlth Sci,Fac Med, Thessaloniki, Greece

[10] Metropolitan Hosp, Dept Med Oncol 2, Piraeus, Greece

[11] Hygeia Hosp, Dept Med Oncol 3, Athens, Greece

[12] Univ Athens, Sch Med, Dept Pathol, Athens, Greece

[13] Evangelismos Med Ctr, Dept Pathol, Athens, Greece

[14] Agii Anargiri Canc Hosp, Dept Med Oncol 2, Athens, Greece

[15] Metropolitan Hosp, Dept Med Oncol 1, Piraeus, Greece

[16] Hippokrateion Hosp, Oncol Unit, Athens, Greece

[17] Univ Athens, Sch Med, Laiko Gen Hosp, Dept Med 1, Athens, Greece

[18] Hellen Cooperat Oncol Grp, Data Off, Translat Res Sect, Athens, Greece

[19] Aristotle Univ Thessaloniki, Thessaloniki, Greece

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 05期

关键词：

Notch2; Notch3; Jagged1; triple-negative breast cancer; prognosis; TUMOR-INFILTRATING LYMPHOCYTES; DENSE SEQUENTIAL CHEMOTHERAPY; RANDOMIZED PHASE-III; TISSUE MICROARRAYS; THERAPEUTIC TARGET; EXPRESSION; EPIRUBICIN; INHIBITION; JAG1; IDENTIFICATION;

D O I：

10.21873/anticanres.11570

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The Notch pathway has been implicated in triple-negative breast cancer (TNBC). Herein, we studied the subcellular localization of the less investigated Notch2 and Notch3 and that of the Jagged1 (Jag1) ligand in patients with operable TNBC. Patients and Methods: We applied immunohistochemistry for Notch2, Notch3 and Jag1 in 333 tumors from TNBC patients treated with adjuvant anthracycline-based chemotherapy. We evaluated cytoplasmic (c), membranous (m) and nuclear (n) protein localization. Results: c-Notch2 (35% positive tumors), c-Notch3 ( 63%), c-Jag1 (43%), m-Notch3 (23%) and n-Jag1 (17%) were analyzed individually and by using hierarchical clustering for prognostic evaluation. Upon multivariate analysis, compared to high m-Notch3 in the absence of n-Jag1 (cluster 4), all other marker combinations (clusters 1, 2, 3) conferred significantly higher risk for relapse (p<0.05). Conclusion: Specific Notch3 and Jag1 subcellular localization patterns may provide clues for the behavior of the tumors and potentially for Jag1 targeting in TNBC patients.

引用

页码：2323 / 2334

页数：12

共 50 条

[41] Prognostic Significance of Lymphocyte Infiltrate Localization in Triple-Negative Breast Cancer
Ceprnja, Toni
Mrklic, Ivana
Peric Balja, Melita
Marusic, Zlatko
Blazicevic, Valerija
Spagnoli, Giulio Cesare
Juretic, Antonio
Capkun, Vesna
Tecic Vuger, Ana
Vrdoljak, Eduard
Tomic, Snjezana
JOURNAL OF PERSONALIZED MEDICINE, 2022, 12 (06):
[42] Inhibition of Notch enhances efficacy of immune checkpoint blockade in triple-negative breast cancer
Shen, Qiang
Murakami, Kiichi
Sotov, Valentin
Butler, Marcus
Ohashi, Pamela S.
Reedijk, Michael
SCIENCE ADVANCES, 2024, 10 (44):
[43] Targeting Notch signaling in cancer stem-like cells of triple-negative breast cancer
Murphy, Adrienne M.
Ucar, Ayse D.
Miele, Lucio
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2022, 31 (01)
[44] Daurisoline Inhibits Progression of Triple-Negative Breast Cancer by Regulating the γ-Secretase/Notch Axis
Zhan, Xiangyi
Chen, Xiaoyong
Feng, Mei
Yao, Kuo
Yang, Kefan
Jia, Hui
BIOMOLECULES & THERAPEUTICS, 2025, 33 (02) : 331 - 343
[45] The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells
Pamarthy, Sahithi
Jaiswal, Mukesh K.
Kulshreshtha, Arpita
Katara, Gajendra K.
Gilman-Sachs, Alice
Beaman, Kenneth D.
ONCOTARGET, 2015, 6 (33) : 34206 - 34220
[46] 佐剂关节炎大鼠肺功能变化与Notch1、Notch2/Jagged1、Jagged2通路的相关性
万磊
刘健
程园园
冯云霞
刘磊
黄传兵
汪元
安徽医科大学学报, 2012, 47 (10) : 1156 - 1160
[47] Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
Wang, Lin
Cao, Ge
Li, Wei
Chen, Xiao-Wen
Xiong, Shi-Shuang
Mu, Ya-Nan
Jiang, Jin-Fang
Yang, Lan
Zhang, De-Rui
Cao, Yu-Wen
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2023, 22
[48] Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
Wang, Lin
Cao, Ge
Li, Wei
Chen, Xiao-Wen
Xiong, Shi-Shuang
Mu, Ya-Nan
Jiang, Jin-Fang
Yang, Lan
Zhang, De-Rui
Cao, Yu-Wen
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2023, 22
[49] Identification of INFG/STAT1/NOTCH3 as γ-Mangostin's potential targets for overcoming doxorubicin resistance and reducing cancer-associated fibroblasts in triple-negative breast cancer
Lawal, Bashir
Wu, Alexander T. H.
Chen, Chien-Hsin
George, T. A.
Wu, Szu-Yuan
BIOMEDICINE & PHARMACOTHERAPY, 2023, 163
[50] Brucine Inhibits Bone Metastasis of Breast Cancer Cells by Suppressing Jagged1/Notch1 Signaling Pathways
HU Ke-fei
KONG Xiang-ying
ZHONG Mi-cun
WAN Hong-ye
LIN Na
PEI Xiao-hua
Chinese Journal of Integrative Medicine , 2017, (02) : 110 - 116

← 1 2 3 4 5 →