Prognostic Subcellular Notch2, Notch3 and Jagged1 Localization Patterns in Early Triple-negative Breast Cancer

被引：14

作者：

Strati, Titika-Marina ^{[1
]}

Kotoula, Vassiliki ^{[2
,3
]}

Kostopoulos, Ioannis ^{[2
]}

Manousou, Kyriaki ^{[4
]}

Papadimitriou, Christos ^{[5
]}

Lazaridis, Georgios ^{[6
]}

Lakis, Sotiris ^{[3
]}

Pentheroudakis, George ^{[7
]}

Pectasides, Dimitrios ^{[8
]}

Pazarli, Elissavet ^{[9
]}

Christodoulou, Christos ^{[10
]}

Razis, Evangelia ^{[11
]}

Pavlakis, Kitty ^{[12
]}

Magkou, Christina ^{[13
]}

Chrisafi, Sofia ^{[3
]}

Aravantinos, Gerasimos ^{[14
]}

Bafaloukos, Dimitrios ^{[15
]}

Papakostas, Pavlos ^{[16
]}

Gogas, Helen ^{[17
]}

Kalogeras, Konstantine T. ^{[3
,18
]}

Fountzilas, George ^{[3
,19
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Surg 3, Sch Hlth Sci,Fac Med, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Sch Hlth Sci, Fac Med, Dept Pathol, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Hellen Fdn Canc Res, Mol Oncol Lab, Thessaloniki, Greece

[4] Hellen Cooperat Oncol Grp, Data Off, Biostat Sect, Athens, Greece

[5] Univ Athens, Sch Med, Alexandra Hosp, Dept Clin Therapeut, Athens, Greece

[6] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Dept Med Oncol, Sch Hlth Sci,Fac Med, Thessaloniki, Greece

[7] Ioannina Univ Hosp, Ioannina, Greece

[8] Hippokrateion Hosp, Dept Internal Med 2, Oncol Sect, Athens, Greece

[9] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Dept Pathol, Sch Hlth Sci,Fac Med, Thessaloniki, Greece

[10] Metropolitan Hosp, Dept Med Oncol 2, Piraeus, Greece

[11] Hygeia Hosp, Dept Med Oncol 3, Athens, Greece

[12] Univ Athens, Sch Med, Dept Pathol, Athens, Greece

[13] Evangelismos Med Ctr, Dept Pathol, Athens, Greece

[14] Agii Anargiri Canc Hosp, Dept Med Oncol 2, Athens, Greece

[15] Metropolitan Hosp, Dept Med Oncol 1, Piraeus, Greece

[16] Hippokrateion Hosp, Oncol Unit, Athens, Greece

[17] Univ Athens, Sch Med, Laiko Gen Hosp, Dept Med 1, Athens, Greece

[18] Hellen Cooperat Oncol Grp, Data Off, Translat Res Sect, Athens, Greece

[19] Aristotle Univ Thessaloniki, Thessaloniki, Greece

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 05期

关键词：

Notch2; Notch3; Jagged1; triple-negative breast cancer; prognosis; TUMOR-INFILTRATING LYMPHOCYTES; DENSE SEQUENTIAL CHEMOTHERAPY; RANDOMIZED PHASE-III; TISSUE MICROARRAYS; THERAPEUTIC TARGET; EXPRESSION; EPIRUBICIN; INHIBITION; JAG1; IDENTIFICATION;

D O I：

10.21873/anticanres.11570

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The Notch pathway has been implicated in triple-negative breast cancer (TNBC). Herein, we studied the subcellular localization of the less investigated Notch2 and Notch3 and that of the Jagged1 (Jag1) ligand in patients with operable TNBC. Patients and Methods: We applied immunohistochemistry for Notch2, Notch3 and Jag1 in 333 tumors from TNBC patients treated with adjuvant anthracycline-based chemotherapy. We evaluated cytoplasmic (c), membranous (m) and nuclear (n) protein localization. Results: c-Notch2 (35% positive tumors), c-Notch3 ( 63%), c-Jag1 (43%), m-Notch3 (23%) and n-Jag1 (17%) were analyzed individually and by using hierarchical clustering for prognostic evaluation. Upon multivariate analysis, compared to high m-Notch3 in the absence of n-Jag1 (cluster 4), all other marker combinations (clusters 1, 2, 3) conferred significantly higher risk for relapse (p<0.05). Conclusion: Specific Notch3 and Jag1 subcellular localization patterns may provide clues for the behavior of the tumors and potentially for Jag1 targeting in TNBC patients.

引用

页码：2323 / 2334

页数：12

共 50 条

[31] Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype
Giuli, M. V.
Giuliani, E.
Screpanti, I.
Bellavia, D.
Checquolo, S.
JOURNAL OF ONCOLOGY, 2019, 2019
[32] Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development
Irvin, DK
Zurcher, SD
Nguyen, T
Weinmaster, G
Kornblum, HI
JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 436 (02) : 167 - 181
[33] Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer
Chu, D.
Zhang, Z.
Zhou, Y.
Wang, W.
Li, Y.
Zhang, H.
Dong, G.
Zhao, Q.
Ji, G.
ANNALS OF ONCOLOGY, 2011, 22 (11) : 2440 - 2447
[34] A molecular approach to triple-negative breast cancer: targeting the Notch signaling pathway
Pardo, Isabele
Fagundes, Pedro Brecheret
de Oliveira, Rafael Santana
Campregher, Paulo Vidal
EINSTEIN-SAO PAULO, 2024, 22 : 1 - 6
[35] NOTCH4 Is a Potential Therapeutic Target for Triple-negative Breast Cancer
Nagamatsu, Iori
Onishi, Hideya
Matsushita, Shojiro
Kubo, Makoto
Kai, Masaya
Imaizumi, Akira
Nakano, Kenji
Hattori, Masami
Oda, Yoshinao
Tanaka, Masao
Katano, Mitsuo
ANTICANCER RESEARCH, 2014, 34 (1A) : 69 - 80
[36] Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer
Jung, Jin-Gyoung
Stoeck, Alexander
Guan, Bin
Wu, Ren-Chin
Zhu, Heng
Blackshaw, Seth
Shih, Ie-Ming
Wang, Tian-Li
PLOS GENETICS, 2014, 10 (10):
[37] NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer
Jia, Dongyu
Underwood, Jesse
Xu, Qiuping
Xie, Qian
ONCOLOGY LETTERS, 2019, 17 (06) : 4914 - 4920
[38] Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas
Lu, Runchun
Gao, Hua
Wang, Hongyun
Cao, Lei
Bai, Jiwei
Zhang, Yazhuo
ONCOLOGY LETTERS, 2013, 5 (03) : 845 - 851
[39] NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1
Liu, Hua
Kennard, Simone
Lilly, Brenda
CIRCULATION RESEARCH, 2009, 104 (04) : 466 - U97
[40] BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling
Andrieu, Guillaume
Tran, Anna H.
Strissel, Katherine J.
Denis, Gerald V.
CANCER RESEARCH, 2016, 76 (22) : 6555 - 6567

← 1 2 3 4 5 →