The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

被引：444

作者：

Van Acker, Heleen ^{[1
]}

Coenye, Tom ^{[1
]}

机构：

[1] Univ Ghent, Lab Pharmaceut Microbiol, Ghent, Belgium

来源：

TRENDS IN MICROBIOLOGY | 2017年 / 25卷 / 06期

关键词：

INDUCED OXIDATIVE STRESS; TOXIN-ANTITOXIN SYSTEMS; PROGRAMMED CELL-DEATH; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; RESISTANCE; CIPROFLOXACIN; RESPONSES; INDUCE;

D O I：

10.1016/j.tim.2016.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, it was proposed that there is a common mechanism behind the activity of bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However, the involvement of ROS in antibiotic-mediated killing has become the subject of much debate. In the present review, we provide an overview of the data supporting the ROS hypothesis; we also present data that explain the contradictory results often obtained when studying antibiotic-induced ROS production. For this latter aspect we will focus on the importance of taking the experimental setup into consideration and on the importance of some technical aspects of the assays typically used. Finally, we discuss the link between ROS production and toxin-antitoxin modules, and present an overview of implications for treatment.

引用

页码：456 / 466

页数：11

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