Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection

被引：48

作者：

Tamez, Pamela A. ^{[1
]}

Liu, Hui ^{[2
]}

Fernandez-Pol, Sebastian ^{[1
]}

Haldar, Kasturi ^{[1
]}

Wickrema, Amittha ^{[2
]}

机构：

[1] Univ Notre Dame, Ctr Rare & Neglected Dis, South Bend, IN 46556 USA

[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA

来源：

BLOOD | 2009年 / 114卷 / 17期

关键词：

ERYTHROID PROGENITOR CELLS; RED-CELL; ERYTHROPOIETIN; EXPRESSION;

D O I：

10.1182/blood-2009-07-231894

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Malaria parasites are known to invade and develop in erythrocytes and reticulocytes, but little is known about their infection of nucleated erythroid precursors. We used an in vitro cell system that progressed through basophilic, polychromatic, orthochromatic, and reticulocyte stages to mature erythrocytes. We show that orthochromatic cells are the earliest stages that may be invaded by Plasmodium falciparum, the causative agent of fatal human malaria. Susceptibility to invasion is distinct from intracellular survival and occurs at a time of extensive erythroid remodeling. Together these data suggest that the potential for complexity of host interactions involved in infection may be vastly greater than hitherto realized. (Blood. 2009;114:3652-3655)

引用

页码：3652 / 3655

页数：4

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