NEUROSCIENCE Editing out fear

被引：21

作者：

Quirk, Gregory J. ^{[1
]}

Milad, Mohammed R. ^{[2
]}

机构：

[1] Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Charlestown, MA 02129 USA

来源：

NATURE | 2010年 / 463卷 / 7277期

关键词：

RECONSOLIDATION; EXTINCTION; MEMORY; CONSOLIDATION; RETRIEVAL;

D O I：

10.1038/463036a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Retrieving a memory initiates a window of vulnerability for that memory. Simple behavioural methods can modify distressing memories during this window, eliminating fear reactions to traumatic reminders.

引用

页码：36 / 37

页数：2

共 10 条

[1] Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? [J].

Alberini, CM .

TRENDS IN NEUROSCIENCES, 2005, 28 (01) :51-56

[2] Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder [J].

Brunet, Alain ;

Orr, Scott P. ;

Tremblay, Jacques ;

Robertson, Kate ;

Nader, Karim ;

Pitman, Roger K. .

JOURNAL OF PSYCHIATRIC RESEARCH, 2008, 42 (06) :503-506

[3] Effects of D-cycloserine on extinction: Translation from preclinical to clinical work [J].

Davis, Michael ;

Ressler, Kerry ;

Rothbaum, Barbara O. ;

Richardson, Rick .

BIOLOGICAL PSYCHIATRY, 2006, 60 (04) :369-375

[4] Beyond extinction: erasing human fear responses and preventing the return of fear [J].

Kindt, Merel ;

Soeter, Marieke ;

Vervliet, Bram .

NATURE NEUROSCIENCE, 2009, 12 (03) :256-258

[5] Neuroscience - Memory - a century of consolidation [J].

McGaugh, JL .

SCIENCE, 2000, 287 (5451) :248-251

[6] Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder [J].

Milad, Mohammed R. ;

Pitman, Roger K. ;

Ellis, Cameron B. ;

Gold, Andrea L. ;

Shin, Lisa M. ;

Lasko, Natasha B. ;

Zeidan, Mohamed A. ;

Handwerger, Kathryn ;

Orr, Scott P. ;

Rauch, Scott L. .

BIOLOGICAL PSYCHIATRY, 2009, 66 (12) :1075-1082

[7] Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories [J].

Monfils, Marie-H. ;

Cowansage, Kiriana K. ;

Klann, Eric ;

LeDoux, Joseph E. .

SCIENCE, 2009, 324 (5929) :951-955

[8] Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval [J].

Nader, K ;

Schafe, GE ;

Le Doux, JE .

NATURE, 2000, 406 (6797) :722-726

[9] A single standard for memory: the case for reconsolidation [J].

Nader, Karim ;

Hardt, Oliver .

NATURE REVIEWS NEUROSCIENCE, 2009, 10 (03) :224-234

[10] Preventing the return of fear in humans using reconsolidation update mechanisms [J].

Schiller, Daniela ;

Monfils, Marie-H. ;

Raio, Candace M. ;

Johnson, David C. ;

LeDoux, Joseph E. ;

Phelps, Elizabeth A. .

NATURE, 2010, 463 (7277) :49-U51

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