Superficial Vancomycin Coating of Bone Cement in Orthopedic Revision Surgery: A Safe Technique to Enhance Local Antibiotic Concentrations

Background: The use of antibiotic-loaded cement has become a well-accepted method to develop high local antibiotic concentrations in revision surgery of infected arthroplasty. A new surgical technique has been established to further increase the local antibiotic concentration and thereby minimizes the risk of reinfection. Our study aim was to investigate the safety of additional superficial vancomycin coating (SVC) by analyzing postoperative joint and serum vancomycin concentrations, as well as the creatinine levels of patients with orthopedic revision surgery. Methods: A longitudinal case series was performed by reviewing collected data of patients who were treated by SVC during revision surgery (1- or 2-stage exchange) because of prosthetic joint infections. Vancomycin levels were obtained, local from drains and systemic from blood samples, on postoperative days 1 to 5. Furthermore, preoperative and postoperative serum creatinine levels were analyzed. Results: Highest median local vancomycin levels were documented on postoperative day 1 with 546.8 mu g/mL (range, 44.4-1485 mu g/mL) in the reimplantation group and 408.7 mu g/mL (range, 24.7-1650 mu g/mL) in the spacer group. Median serum vancomycin level was 4.4 mu g/mL (range, <2.0-11.7 mu g/mL) on the first postoperative day in the reimplantation group and <2.0 mu g/mL (range, <2.0-3.9 mu g/mL) in the spacer group, and lower than 2.0 mu g/mL (range, <2.0-7.5 mu g/mL) from postoperative day 2 to 5 in both groups. Neither an anaphylactic reaction nor other side effects to SVC were observed. Conclusion: Our data showed that SVC of bone cement is an effective technique to enhance local concentrations of vancomycin without leading to systemic side effects. (C) 2016 Elsevier Inc. All rights reserved.