Vitreous fluid biomarkers

被引：11

作者：

Funatsu, Hideharu ^{[1
]}

Yamashita, Tetsuji

Yamashita, Hidetoshi

机构：

[1] Tokyo Womens Med Univ, Dept Ophthalmol, Ctr Diabet, Tokyo, Japan

[2] Mitsubishi Kagaku Bio Clin Labs Inc, Informat Mkt Dept, Tokyo, Japan

[3] Yamagata Univ, Sch Med, Dept Ophthalmol & Visual Sci, Yamagata 990, Japan

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 42 | 2006年 / 42卷

关键词：

D O I：

10.1016/S0065-2423(06)42004-7

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Interactions between cells and the network of secreted proteins are associated with the ocular disease. In most cases, clinical appearcance is sufficiently diagnostic. However, in cases of nonspecific or atypical clinical presentation, diagnostic sampling of vitreous fluid can aid diagnosis and treatment for ocular disease. Progresses in the basic sciences, particularly molecular biology, and advances in surgical instrumentation have greatly enhanced the diagnostic armamentarium. These developments also have led to a better understanding of the pathophysiological processes involved in ocular diseases and have prompted evolution of new therapeutic modalities. In this chapter, we review techniques for vitreous fluid sampling and biomarker quantitation thereof. The molecular biology of bioactive vitreous fluid factors is also discussed with respect to their clinical involvement in the development of ocular disease.

引用

页码：111 / 166

页数：56

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