Role of Vitamin C in Prevention of Preeclampsia in High-Risk Cases: Randomized Controlled Trial

被引：1

作者：

Torky, Haitham A. ^{[1
,2
]}

Abo-Louz, Ashraf ^{[1
,2
]}

Deif, Osama ^{[2
,3
]}

Moussa, Asem ^{[2
,3
]}

Aly, Rania ^{[2
,4
]}

Shata, Atef ^{[2
,5
]}

Ragab, Mona ^{[6
]}

El-Taher, Osama S. ^{[6
]}

Hussein, Ahmed ^{[1
,2
]}

机构：

[1] October 6th Univ, Dept Obstet & Gynecol, Cairo, Egypt

[2] Air Force Specialized Hosp, Cairo, Egypt

[3] Al Azhar Univ, Dept Obstet & Gynecol, Cairo, Egypt

[4] Al Galaa Teaching Hosp, Dept Obstet & Gynecol, Cairo, Egypt

[5] Matariya Teaching Hosp, Dept Obstet & Gynecol, Cairo, Egypt

[6] Al Galaa Teaching Hosp, Air Force Specialized Hosp, Dept Obstet & Gynecol, Cairo, Egypt

来源：

INTERNATIONAL JOURNAL OF CHILDBIRTH | 2021年 / 11卷 / 01期

关键词：

preeclampsia; prevention; high-risk; vitamin C; OXIDATIVE STRESS; ANTIOXIDANTS; PREGNANCY;

D O I：

10.1891/IJCBIRTH-D-20-00027

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

OBJECTIVE: To evaluate the effect of vitamin C intake on the incidence of preeclampsia in high-risk cases. METHODOLOGY: Prospective double-blinded multi-center randomized controlled trial involving 940 qualified patients equally divided into two groups one receiving vitamin C and the other receiving placebo starting from 12 weeks gestational age. RESULTS: No significant difference was found between vitamin C and placebo on the incidence of preeclampsia, maternal problems (prelabor rupture of membranes, antepartum hemorrhage, and placental abruption), and fetal outcomes (birth weight, Apgar scores, preterm delivery, admission to NICU, and low birth weight). CONCLUSION: Vitamin C intake in pregnancy is not recommended for prevention of preeclampsia, maternal or fetal problems in cases at high-risk for developing preeclampsia.

引用

页码：20 / 26

页数：7

共 20 条

[1] [Anonymous], 2020, Obstet Gynecol, V135, P1492, DOI [10.1097/AOG.0000000000003018, 10.1097/AOG.0000000000003892]
[2] [Anonymous], 2002, OBSTET GYNECOL, V99, P159
[3] [Anonymous], REC PREV TREATM PREE
[4] Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
Duckitt, K
Harrington, D
[J]. BRITISH MEDICAL JOURNAL, 2005, 330 (7491): : 565 - 567
[5] Oxidative stress in the pathogenesis of preeclampsia
Hubel, CA
[J]. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 222 (03): : 222 - 235
[6] Hung Tai-Ho, 2006, Taiwan J Obstet Gynecol, V45, P189
[7] Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women
Klemmensen, A. K.
Tabor, A.
Osterdal, M. L.
Knudsen, V. K.
Halldorsson, T. I.
Mikkelsen, T. B.
Olsen, S. F.
[J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2009, 116 (07) : 964 - 974
[8] Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins
Lee, SH
Oe, T
Blair, IA
[J]. SCIENCE, 2001, 292 (5524) : 2083 - 2086
[9] Lowe SA, 2014, GUIDELINE MANAGEMENT
[10] Role of antioxidants in gestational diabetes mellitus and relation to fetal outcome: a randomized controlled trial (Publication with Expression of Concern. See DEC, 2022)
Maged, Ahmed M.
Torky, Haitham
Fouad, Mona A.
GadAllah, Sherine H.
Waked, Nevien M.
Gayed, Ahmed S.
Salem, Ashraf K.
[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2016, 29 (24) : 4049 - 4054

← 1 2 →