Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance

被引：56

作者：

Cao, Yihai ^{[1
]}

Zhong, Weide ^{[2
]}

Sun, Yan ^{[3
,4
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

[2] Guangzhou First Municipal Peoples Hosp, Dept Urol, Guangzhou, Peoples R China

[3] Chinese Acad Sci, Dept Med Oncol, Canc Hosp, Beijing 100021, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2009年 / 19卷 / 05期

基金：

瑞典研究理事会;

关键词：

Growth factor; Angiogenesis; Drug resistance; Cancer; Metastasis; ENDOTHELIAL GROWTH-FACTOR; LIGAND-INDEPENDENT ACTIVATION; INHIBITS TUMOR-GROWTH; BONE-MARROW; PDGF-BB; CELLS; VEGF; BEVACIZUMAB; RECRUITMENT; VASCULATURE;

D O I：

10.1016/j.semcancer.2009.05.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several antiangiogenic agents, including bevacizumab, sunitinib, and sorafenib, which mainly target the VEGF signaling system, have been approved for the treatment of human cancers. These drugs have been paired with conventional chemotherapeutic agents to treat different types of cancers, including colorectal and lung cancers; however, the patient response rate and resultant increase in overall survival time have been rather modest. The current antiangiogenic regimen is far from optimal. Improvements of therapeutic efficacy and minimization of adverse effects and drug resistance are urgent tasks that are most likely to be resolved by understanding the molecular mechanisms underlying tumor angiogenesis. The aim of this article is to discuss these clinically related issues, to highlight several recent examples of the complex interplays between tumor-produced angiogenic factors, and to propose a new paradigm for improvement of therapeutic intervention of tumor angiogenesis. (C) 2009 Published by Elsevier Ltd.

引用

页码：338 / 343

页数：6

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