Metal-free, Visible-Light-Induced Radical Trifluoromethylation/Cyclization of N-benzamides with CF3SO2Na to Synthesize CF3-Containing Isoquinoline-1,3-diones

被引：17

作者：

Wang, Shaowei ^{[1
,2
]}

Dai, Peng ^{[1
,2
]}

Yan, Zhichao ^{[1
,2
]}

Wang, Youjia ^{[1
,2
]}

Shao, Jiaxuan ^{[1
,2
]}

Wu, Yanhui ^{[1
,2
]}

Deng, Chao ^{[1
,2
]}

Zhang, Weihua ^{[1
,2
]}

机构：

[1] Nanjing Agr Univ, Coll Sci, Jiangsu Key Lab Pesticide Sci, Nanjing 210095, Jiangsu, Peoples R China

[2] Nanjing Agr Univ, Coll Sci, Dept Chem, Nanjing 210095, Jiangsu, Peoples R China

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 35期

关键词：

antifungal activity; Isoquinoline-1; 3-diones; Photo-Induced; Trifluoromethylation; FLUORINATED SULFONES; CATALYTIC HYDROTRIFLUOROMETHYLATION; SELECTIVE INHIBITORS; AROMATIC-ALDEHYDES; ALKENES; DIFUNCTIONALIZATION; CYCLIZATION; CARBOTRIFLUOROMETHYLATION; OXYTRIFLUOROMETHYLATION; FUNCTIONALIZATION;

D O I：

10.1002/slct.201902545

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel visible-light-induced radical cascade trifluoromethylation/cyclization of N-benzamides with CF3SO2Na has been achieved. This protocol provides an efficient strategy for the synthesis of CF3-containing isoquinoline-1,3-diones under mild reaction conditions. The reaction features metal-free, air oxidation, CF3SO2Na as CF3 source, additives free and operational simplicity. Moreover, the representative products displayed significant potencial antifungal activities in vitro.

引用

页码：10329 / 10333

页数：5

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