Application of contrast-enhanced ultrasound in the diagnosis of post-transplant lymphoproliferative disease after hematopoietic stem cell transplantation A case report

被引:3
作者
Chen, Weinan [1 ]
Li, Jianchun [1 ]
Fan, Xiaoming [1 ]
Zhang, Yanming [1 ]
Wang, Li [1 ]
Liu, Yang [1 ]
Cui, Ailin [1 ]
Wang, Ligang [1 ]
机构
[1] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
关键词
contrast-enhanced ultrasound; hematopoietic stem cell transplantation; post-transplant lymphoproliferative disease; DISORDER; RISK;
D O I
10.1097/MD.0000000000024047
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Post-transplant lymphoproliferative disease (PTLD) is a series of proliferative diseases of the lymphatic system. Among patients receiving hematopoietic stem cell transplantation (HSCT), PTLD is a prevalent complication that severely affects rates of survival. Ultrasound plays an essential role in the early diagnosis of PTLD. Contrast-enhanced ultrasonography (CEUS) and CEUS-guided biopsy are critical procedures for tumor diagnosis. Patient concerns: Herein, we report the case of a 40-year-old male patient with acute lymphoblastic leukemia who received HSCT more than 1 year ago. Sonography revealed a small hypoechoic nodule in the liver four months after HSCT. Eight months after HSCT, larger and more nodules were observed via ultrasound; CT was used to identify the lesions. Diagnoses: CEUS and CEUS-guided biopsy were performed, and the pathological diagnosis was PTLD. Interventions: The final clinical diagnosis was PTLD, and cyclophosphamide, epirubicin, and dexamethasone were administered as chemotherapy. Outcomes: The patient was discharged after his condition improved. Conclusion: Ultrasound can be used to effectively detect lesions of PTLD early after HSCT. Furthermore, CEUS and CEUS-guided biopsy were effective for early confirmatory diagnoses of PTLD after HSCT.
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页数:5
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