Comparison of physicochemical properties of suppositories containing starch hydrolysates

被引：12
作者：
Belniak, Piotr [1 ]
Swiader, Katarzyna [1 ]
Szumilo, Michal [1 ]
Hyla, Aleksandra [1 ]
Poleszak, Ewa [1 ]
机构：
[1] Med Univ Lublin, Fac Pharm, Chair & Dept Apply Pharm, 1 Chodzki St, PL-20093 Lublin, Poland
来源：
SAUDI PHARMACEUTICAL JOURNAL | 2017年 / 25卷 / 03期
关键词：
Starch hydrolysate; Acetaminophen; Suppositories; Flow-through apparatus; SUSTAINED-RELEASE; DICLOFENAC;
D O I：
10.1016/j.jsps.2016.09.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this work was to determine the effect of starch hydrolysates (SH) on the physicochemical properties of suppositories. The study was conducted with suppositories with acetaminophen (AAP) a typical antipyretic analgesic, as model drug on lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). The suppositories with and without the addition of SH were examined for physicochemical tests according to European Pharmacopoeia 8th edition (Ph. Eur.): the uniformity of mass of single-dose preparation test, the softening time determination of lipophilic suppositories test, the disintegration of suppositories test, and dissolution test with flow-through apparatus. The results confirm the possibility of using starch hydrolysates as a cheap and safe addition to modify physicochemical properties of suppositories. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：365 / 369
页数：5
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