Prognosis Prediction Using Magnetic Resonance Spectroscopy and Oligoclonal Bands in Central Nervous System Methotrexate-associated Lymphoproliferative Disorder

被引：1
|
作者：
Ueno, Hiroki [1 ]
Ohno, Narumi
Abe, Takafumi
Kimoto, Kazuki
Matsuoka, Chika
Giga, Mayumi
Naito, Hiroyuki
Kono, Tomoyuki
Takasu, Miyuki
Kidani, Naoya
Yamasaki, Rie
Ichimura, Koichi
Nomura, Eiichi
机构：
[1] Hiroshima City Hiroshima Citizens Hosp, Dept Neurol, Hiroshima, Japan
来源：
INTERNAL MEDICINE | 2022年 / 61卷 / 24期
关键词：
methotrexate-associated lymphoproliferative disorder; EBV; MRS; oligoclonal bands; EPSTEIN-BARR-VIRUS; RHEUMATOID-ARTHRITIS; LYMPHOMA; PATIENT;
D O I：
10.2169/internalmedicine.9296-21
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Central nervous system methotrexate-associated lymphoproliferative disorder (CNS-MTX-LPD) is rare, but its spontaneous regression has been observed in some patients after withdrawal of agents. We herein report three cases of primary CNS-MTX-LPD that received oral MTX for rheumatoid arthritis. Epstein-Barr virus and oligoclonal bands (OCBs) were positive, while proton magnetic resonance spectroscopy (1H-MRS) showed an elevated lipid peak and slightly elevated choline/N-acetylaspartate ratio in common. After MTX withdrawal, brain lesions showed spontaneous regression in all cases. Our patient's 1H-MRS findings and OCBs may reflect a non-monoclonal lymphoproliferative histology as benign-type lesions in CNS-MTX-LPD.
引用
收藏
页码：3733 / 3738
页数：6
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