Targeting cyclin-dependent kinases in anti-neoplastic therapy

被引：77

作者：

Bruyere, Celine ^{[1
]}

Meijer, Laurent ^{[1
]}

机构：

[1] ManRos Therapeut, Ctr Perharidy, F-29680 Roscoff, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 06期

关键词：

PROTEIN RECOGNITION PROPERTIES; LYMPHOCYTIC-LEUKEMIA CELLS; BREAST-CANCER; CDK INHIBITORS; CRYSTAL-STRUCTURE; DOWN-REGULATION; CHEMICAL INHIBITORS; N-MYC; COMPLEX; PHOSPHORYLATION;

D O I：

10.1016/j.ceb.2013.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell cycle progression is controlled by sequential activation of cyclin-dependent kinases (CDKs), which are often deregulated in cancer. Consequently numerous pharmacological inhibitors of CDKs have been developed with the aim of treating cancers. The article briefly reviews CDK inhibitors and their use to treat cancers, with specific focus on the use of biomarkers and drugs combination to improve their therapeutic efficacy.

引用

页码：772 / 779

页数：8

共 84 条

[1] ATP-noncompetitive CDK inhibitors for cancer therapy: an overview [J].

Abate, Agnese Anna ;

Pentimalli, Francesca ;

Esposito, Luca ;

Giordano, Antonio .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2013, 22 (07) :895-906

[2] Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E [J].

Akli, Said ;

Van Pelt, Carolyn S. ;

Bui, Tuyen ;

Meijer, Laurent ;

Keyomarsi, Khandan .

CANCER RESEARCH, 2011, 71 (09) :3377-3386

[3] Potent Antimyeloma Activity of a Novel ERK5/CDK Inhibitor [J].

Alvarez-Fernandez, Stela ;

Jesus Ortiz-Ruiz, Maria ;

Parrott, Tracy ;

Zaknoen, Sara ;

Ocio, Enrique M. ;

San Miguel, Jesus ;

Burrows, Francis J. ;

Esparis-Ogando, Azucena ;

Pandiella, Atanasio .

CLINICAL CANCER RESEARCH, 2013, 19 (10) :2677-2687

[4] Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis [J].

An, Xiaomeng ;

Ng, Samuel S. ;

Xie, Dan ;

Zeng, Yi-Xin ;

Sze, Johnny ;

Wang, Jide ;

Chen, Yang Chao ;

Chow, Billy K. C. ;

Lu, Gang ;

Poon, Wai Sang ;

Kung, Hsiang-fu ;

Wong, Benjamin C. Y. ;

Lin, Marie Chia-mi .

EUROPEAN JOURNAL OF CANCER, 2010, 46 (09) :1752-1761

[5] Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity [J].

Anastassiadis, Theonie ;

Deacon, Sean W. ;

Devarajan, Karthik ;

Ma, Haiching ;

Peterson, Jeffrey R. .

NATURE BIOTECHNOLOGY, 2011, 29 (11) :1039-U117

[6] Roscovitine targets, protein kinases and pyridoxal kinase [J].

Bach, S ;

Knockaert, M ;

Reinhardt, J ;

Lozach, O ;

Schmitt, S ;

Baratte, B ;

Koken, M ;

Coburn, SP ;

Tang, L ;

Jiang, T ;

Liang, DC ;

Galons, H ;

Dierick, JF ;

Pinna, LA ;

Meggio, F ;

Totzke, F ;

Schächtele, C ;

Lerman, AS ;

Carnero, A ;

Wan, YQ ;

Gray, N ;

Meijer, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (35) :31208-31219

[7]

Baker Stacey J, 2012, Genes Cancer, V3, P658, DOI 10.1177/1947601913478972

[8] The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation [J].

Baumli, Sonja ;

Lolli, Graziano ;

Lowe, Edward D. ;

Troiani, Sonia ;

Rusconi, Luisa ;

Bullock, Alex N. ;

Debreczeni, Judit E. ;

Knapp, Stefan ;

Johnson, Louise N. .

EMBO JOURNAL, 2008, 27 (13) :1907-1918

[9] Characterization of Cyclin E Expression in Multiple Myeloma and Its Functional Role in Seliciclib-Induced Apoptotic Cell Death [J].

Ben-Yehoshua, Liat Josefsberg ;

Beider, Katia ;

Shimoni, Avichai ;

Ostrovsky, Olga ;

Samookh, Michal ;

Peled, Amnon ;

Nagler, Arnon .

PLOS ONE, 2012, 7 (04) :e33856

[10] CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases [J].

Bettayeb, K. ;

Oumata, N. ;

Echalier, A. ;

Ferandin, Y. ;

Endicott, J. A. ;

Galons, H. ;

Meijer, L. .

ONCOGENE, 2008, 27 (44) :5797-5807

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