Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

被引：32

作者：

Cherkaoui, S ^{[1
]}

Mateus, L ^{[1
]}

Christen, P ^{[1
]}

Veuthey, JL ^{[1
]}

机构：

[1] Univ Geneva, Lab Pharmaceut Analyt Chem, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 21卷 / 01期

关键词：

atropine and scopolamine derivatives; pharmaceuticals; capillary electrophoresis; nonaqueous media;

D O I：

10.1016/S0731-7085(99)00141-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple nonaqueous capillary electrophoresis method is described for the separation of several atropine and scopolamine related drugs. The analysis of these pharmaceutical compounds was performed in a methanol-acetonitrile (25/75, v/v) mixture containing 25 mM ammonium acetate and 1 M acetic acid. The robustness was proved using a full factorial design at two levels. The method was validated and successfully applied for the determination of N-butylscopolamine in different pharmaceutical preparations. Results were compared to those obtained by a capillary electrophoresis method based on aqueous media. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：165 / 174

页数：10

共 25 条

[21] VARIATION IN THE TROPANE ALKALOID CONTENT OF HYOSCYAMUS-MUTICUS PLANTS AND CELL-CULTURE CLONES [J].

OKSMANCALDENTEY, KM ;

VUORELA, H ;

STRAUSS, A ;

HILTUNEN, R .

PLANTA MEDICA, 1987, (04) :349-354

[22] Coelectroosmotic separations of anions in non-aqueous capillary electrophoresis [J].

Tjornelund, J ;

Bazzanella, A ;

Lochmann, H ;

Bächmann, K .

JOURNAL OF CHROMATOGRAPHY A, 1998, 811 (1-2) :211-217

[23]

Valko I.E., 1997, LC GC EUR, V3, P190

[24] Chiral separation of dansyl-amino acids in a nonaqueous medium by capillary electrophoresis [J].

Valko, IE ;

Siren, H ;

Riekkola, ML .

JOURNAL OF CHROMATOGRAPHY A, 1996, 737 (02) :263-272

[25] Micellar electrokinetic chromatography of scopolamine-related anticholinergics [J].

Wu, HL ;

Huang, CH ;

Chen, SH ;

Wu, SM .

JOURNAL OF CHROMATOGRAPHY A, 1998, 802 (01) :107-113

← 1 2 3 →