A circadian clock nanomachine that runs without transcription or translation

被引：22

作者：

Egli, Martin ^{[1
]}

Johnson, Carl Hirschie ^{[2
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Coll Arts & Sci, Dept Biol Sci, Nashville, TN 37235 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2013年 / 23卷 / 05期

基金：

美国国家卫生研究院;

关键词：

STIMULATED KAIC PHOSPHORYLATION; SYNECHOCOCCUS-ELONGATUS; GENE-EXPRESSION; CELL-DIVISION; PROTEIN KAIA; CRYSTAL-STRUCTURE; ATPASE ACTIVITY; CYANOBACTERIA; OSCILLATOR; FEEDBACK;

D O I：

10.1016/j.conb.2013.02.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The biochemical basis of circadian timekeeping is best characterized in cyanobacteria. The structures of its key molecular players, KaiA, KaiB, and KaiC are known and these proteins can reconstitute a remarkable circadian oscillation in a test tube. KaiC is rhythmically phosphorylated and its phospho-status is a marker of circadian phase that regulates ATPase activity and the oscillating assembly of a nanomachine. Analyses of the nanomachines have revealed how their timing circuit is ratcheted to be unidirectional and how they stay in synch to ensure a robust oscillator. These insights are likely to elucidate circadian timekeeping in higher organisms, including how transcription and translation could appear to be a core circadian timer when the true pacemaker is an embedded biochemical oscillator.

引用

页码：732 / 740

页数：9

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