Intensity-modulated radiation therapy as primary treatment for oropharyngeal squamous cell carcinoma

被引：25

作者：

May, James T. ^{[1
]}

Rao, Nikhil ^{[1
]}

Sabater, Roberto D. ^{[1
]}

Boutrid, Hinda ^{[1
]}

Caudell, Jimmy J. ^{[1
]}

Merchant, Faisal ^{[1
]}

Han, Gang ^{[1
]}

Padhya, Tapan A. ^{[1
]}

McCaffrey, Judith C. ^{[1
]}

Tanvetyanon, Tawee ^{[1
]}

Deconti, Ronald ^{[1
]}

Kish, Julie ^{[1
]}

McCaffrey, Thomas V. ^{[1
]}

Trotti, Andy ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Head & Neck Oncol Program, Tampa, FL 33612 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 12期

关键词：

intensity-modulated radiation therapy; head and neck cancer; oropharyngeal carcinoma; treatment toxicity; disease control; QUALITY-OF-LIFE; HUMAN-PAPILLOMAVIRUS; NECK-CANCER; DEFINITIVE RADIOTHERAPY; CONCURRENT CHEMOTHERAPY; HEAD; PATTERNS; FAILURE; INFECTION; SURVIVAL;

D O I：

10.1002/hed.23245

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundOver the past decade, intensity-modulated radiation therapy (IMRT) has gained widespread use in the treatment of head and neck cancer. MethodsAll patients with squamous cell carcinoma of the oropharynx treated with primary IMRT with or without chemotherapy over a 5-year period were reviewed. Outcomes and morbidity were analyzed and compared with previously published data. ResultsIn all, 170 patients were included in the analysis. The 3-year local control, locoregional control, disease-free survival, and overall survival rates were 92%, 91%, 80%, and 87%, respectively. Feeding tubes were present in 55% of patients during treatment, but remained in only 1% 2 years following treatment. ConclusionsThis study confirms that IMRT yields excellent treatment outcomes for oropharyngeal carcinoma. Although acute toxicity remains a problem, late toxicity rates are low and long-term feeding tube dependence is rare compared with conventional radiation therapy. (c) 2013 Wiley Periodicals, Inc. Head Neck 35: 1796-1800, 2013

引用

页码：1796 / 1800

页数：5

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