Preparation and evaluation of a polymer-supported Mukaiyama reagent

被引：29

作者：

Convers, E ^{[1
]}

Tye, H ^{[1
]}

Whittaker, M ^{[1
]}

机构：

[1] Evotec OAI, Abingdon OX14 4SD, Oxon, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 17期

关键词：

Mukaiyama reagent; carbodiimide; guanidines;

D O I：

10.1016/j.tetlet.2004.03.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a polymer-supported Mukaiyama reagent is described. This preparation was thoroughly optimized using a DoE approach to achieve optimum loading, and the procedure was successfully applied to prepare the supported reagent on a 10 g scale. This reagent proved to be effective for the formation of carbodiimides through the dehydration of thioureas and for a one-pot guanylation of primary amines. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3401 / 3404

页数：4

共 4 条

[1] An efficient, stereoselective solid-phase synthesis of β-lactams using Mukaiyama's salt for the Staudinger reaction [J].