Recalcitrant Palmar-Plantar Atopic Dermatitis Successfully Treated with Dupilumab: A Case Series

被引：6
作者：
Deng, Lin [1 ]
Luo, Yingzhi [1 ]
An, Binyi [2 ]
Su, Ming [1 ]
Sang, Hong [3 ]
Liu, Fang [3 ]
机构：
[1] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Dermatol, Sch Med, Hangzhou 310006, Peoples R China
[2] Nanjing Med Univ, Jinling Hosp, Dept Dermatol, Nanjing 210002, Peoples R China
[3] Nanjing Univ, Jinling Hosp, Dept Dermatol, Med Sch, Nanjing 210002, Peoples R China
来源：
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2022年 / 15卷
关键词：
atopic dermatitis; dupilumab; palmar-plantar; HAND ECZEMA;
D O I：
10.2147/CCID.S383327
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: Palmar-plantar atopic dermatitis is a common and debilitating condition with significant diagnostic and management challenges.Case Presentation: The paper presents the successful treatment of dupilumab in five female patients with recalcitrant palmar-plantar atopic dermatitis.Methods: The Hand Eczema Severity Index (HECSI) and the Foot Eczema Severity Index (FECSI), eosinophils and IgE levels were evaluated before and after the treatment.Results: Five recalcitrant palmar-plantar atopic dermatitis patients had substantial responses to dupilumab and the persistent pruritus was soon alleviated during the therapy. By week 16, all patients' palmar-plantar eczema has been almost clear, with significant decrease of HECSI and FECSI. The count of eosinophils and IgE levels returned to normal in all patients.Conclusion: Dupilumab significantly improves disease severity and reduces eosinophils and IgE in refractory palmar-plantar AD patients.
引用
收藏
页码：2421 / 2426
页数：6
相关论文
共 15 条
  • [1] Type 2 immunity in the skin and lungs
    Akdis, Cezmi A.
    Arkwright, Peter D.
    Bruggen, Marie-Charlotte
    Busse, William
    Gadina, Massimo
    Guttman-Yassky, Emma
    Kabashima, Kenji
    Mitamura, Yasutaka
    Vian, Laura
    Wu, Jianni
    Palomares, Oscar
    [J]. ALLERGY, 2020, 75 (07) : 1582 - 1605
  • [2] [Anonymous], EFF SAF DUP CHRON HA
  • [3] Patient-Reported Outcome Measures in Atopic Dermatitis and Chronic Hand Eczema in Adults
    Barrett, Amy
    Hahn-Pedersen, Julie
    Kragh, Nana
    Evans, Emily
    Gnanasakthy, Ari
    [J]. PATIENT-PATIENT CENTERED OUTCOMES RESEARCH, 2019, 12 (05) : 445 - 459
  • [4] Off-label use of dupilumab for the treatment of moderate to severe atopic dermatitis in children aged below 6 years of age: a case series
    Da, J.
    Ali, K.
    Lu, K.
    Lou, H.
    Qiu, Y.
    Shan, J.
    Wu, L.
    [J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2022, 47 (02) : 423 - 425
  • [5] Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges
    Dubin, Celina
    Del Duca, Ester
    Guttman-Yassky, Emma
    [J]. THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2020, 16 : 1319 - 1332
  • [6] The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. A study of inter- and intraobserver reliability
    Held, E
    Skoet, R
    Johansen, JD
    Agner, T
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2005, 152 (02) : 302 - 307
  • [7] Kamata Masahiro, 2021, JID Innov, V1, P100042, DOI 10.1016/j.xjidi.2021.100042
  • [8] Current and emerging therapies for hand eczema
    Lee, Griffin R.
    Maarouf, Melody
    Hendricks, Aleksi K.
    Lee, Dylan E.
    Shi, Vivian Y.
    [J]. DERMATOLOGIC THERAPY, 2019, 32 (03)
  • [9] Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study
    Oosterhaven, Jart A. F.
    Voorberg, Angelique N.
    Romeijn, Geertruida L. E.
    de Bruin-Weller, Marjolein S.
    Schuttelaar, Marie L. A.
    [J]. JOURNAL OF DERMATOLOGY, 2019, 46 (08) : 680 - 685
  • [10] Dupilumab Treatment of Very Severe Refractory Atopic Hand Eczema
    Oosterhaven, Jart A. F.
    Romeijn, Geertruida L. E.
    Schuttelaar, Marie L. A.
    [J]. JAMA DERMATOLOGY, 2018, 154 (08) : 969 - 970
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