The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

被引：99
作者：
Janciauskiene, Sabina [1 ,2 ]
Wrenger, Sabine [1 ]
Immenschuh, Stephan [3 ]
Olejnicka, Beata [4 ]
Greulich, Timm [5 ]
Welte, Tobias [1 ]
Chorostowska-Wynimko, Joanna [2 ]
机构：
[1] Hannover Med Sch, Biomed Res Endstage & Obstruct Lung Dis Hannover, Dept Resp Med, Hannover, Germany
[2] Natl Inst TB & Lung Dis, Dept Genet & Clin Immunol, Warsaw, Poland
[3] Hannover Med Sch, Inst Transfus Med, Hannover, Germany
[4] Trelleborg Hosp, Dept Med, Trelleborg, Sweden
[5] Univ Marburg, Univ Hosp Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany
来源：
FRONTIERS IN PHARMACOLOGY | 2018年 / 9卷
关键词：
neutrophil granulocyte; Alpha1-Antitrypsin; acute phase protein; innate immunity; inflammation; proteases; cytokines; neutrophil degranulation; TUMOR-NECROSIS-FACTOR; OBSTRUCTIVE PULMONARY-DISEASE; ACUTE-PHASE PROTEINS; OXIDIZED ALPHA-1-PROTEINASE INHIBITOR; HUMAN POLYMORPHONUCLEAR NEUTROPHILS; ANTI-LACTOFERRIN ANTIBODIES; BLOOD MONONUCLEAR-CELLS; AIRWAY EPITHELIAL-CELLS; ACUTE LUNG INJURY; ALPHA-1-ANTITRYPSIN DEFICIENCY;
D O I：
10.3389/fphar.2018.00341
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.
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页数：13
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