Electrophilic N-amination of two quinazoline-2,4-diones using substituted (nitrophenyl)hydroxylamines

被引：26

作者：

Boyles, DC

Curran, TT

Parlett, RV

机构：

[1] Pfizer Global Res & Dev, Chem Res & Dev, Ann Arbor, MI 48105 USA

[2] Pfizer Global Res & Dev, Chem Res & Dev, Hazard Evaluat Lab, Holland, MI 49424 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2002年 / 6卷 / 03期

关键词：

D O I：

10.1021/op010239f

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The preparation of a few (nitrophenyl)hydroxylamines and reaction with two quinazoline-2,4-diones is described. The electrophilic aminating agents were assessed in terms of yield for the N-amination of two quinazoline-2,4-diones and safety considerations for rapid scale-up. For the amination of the described system, the best yield and the highest onset temperature were found in the same aminating agent, specifically, (4-nitrophenyl)hydroxylamine.

引用

页码：230 / 233

页数：4

共 6 条

[1]

Bird P, 2001, United States Patent, Patent No. [0153273, WO 01/53273 A1]

[2]

KOHLER J, 1993, EXPLOSIVES, P371

[3] AMINATION OF ESTER ENOLATES WITH ORTHO-(2,4-DINITROPHENYL)HYDROXYLAME [J].