Design and Synthesis of Novel 2-Substituted-Benzyl-5-(2-Methylbenzofuran-3-yl)-2H-Tetrazoles: Anti-Proliferative Activity

被引：1
|
作者：
Mokenapelli, Sudhakar [1 ]
Gutam, Madhu [1 ]
Yerrabelli, Jayaprakash Rao [1 ]
Irlapati, Vamshi Krishna [2 ]
Gorityala, Neelima [2 ]
Sagurthi, Someswar Rao [2 ]
Chitneni, Prasad Rao [1 ]
机构：
[1] Osmania Univ, Dept Chem, Nat Prod Lab, Hyderabad 500007, Telangana, India
[2] Osmania Univ, Dept Genet & Biotechnol, Hyderabad 500007, Telangana, India
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2020年 / 46卷 / 05期
关键词：
benzofuran; tetrazoles; anti-proliferative activity; molecular docking; SAR studies; BENZOFURAN DERIVATIVES; ANTIINFLAMMATORY EVALUATION; CYTOTOXIC ACTIVITY; TETRAZOLE; INHIBITORS; POTENT; AGENTS; PART; TOXICITY;
D O I：
10.1134/S1068162020050179
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of 2,5-regioselective benzofuran-tetrazole hybrids (XIIIa-XIIIp) were synthesised from 2H-chromene-3-carbonitriles (IXa), (IXb) in multi steps approach under mild reaction conditions in good yields and evaluated their anti-proliferative activity against HCT116 and Miapaca2 cell lines. Wherein compounds (XIIIe) (IC50: 3.19 mu M) and (XIIIm) (IC50: 2.25 mu M) were displayed highest anti-proliferative activity in both cell lines. Molecular docking and SAR studies revealed the in vitro results with target Proto-oncogene tyrosine kinase Src protein.
引用
收藏
页码：845 / 855
页数：11
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