Pharmacokinetics of Coenzyme Q10

被引：10

作者：

Kalenikova, E. I. ^{[1
]}

Gorodetskaya, E. A. ^{[1
]}

Medvedev, O. S. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Basic Med, Dept Pharmacol, Moscow 117234, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

coenzyme Q(10); solubilized form; pharmacokinetics; bioavailability;

D O I：

10.1007/s10517-008-0270-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pharmacokinetics of coenzyme Q(10) powder and solution of solubilized form was studied after their oral administration to rats (10 mg/kg). Plasma concentrations of coenzyme Q(10) were measured by HPLC with electrochemical detection over 48 hours. Solubilized coenzyme Q(10) exhibited high absorption creating higher plasma concentrations of the drug, as a result of which its bioavailability constituted 264% of that for the powder.

引用

页码：313 / 316

页数：4

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