The role of adiponectin in atherosclerosis and thrombosis

被引：63
作者：
Ekmekci, Hakan
Ekmekci, Ozlem B.
机构：
[1] Istanbul Univ, Fac Med, Dept Pediat Haematol & Oncol, Istanbul, Turkey
[2] Istanbul Univ, Bone Marrow Transplantat Unit, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2006年 / 12卷 / 02期
关键词：
adiponectin; atheroscierosis; thrombosis;
D O I：
10.1177/107602960601200203
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. it can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, and suppressing the accumulation of modified lipoproteins in the vascular wall. In addition, as adiponectin decrease endothelial damage and stimulates production of NO from vascular endothelial cells, hypoadiponectinemia may be partially contribute to thrombus formation.
引用
收藏
页码：163 / 168
页数：6
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