Synthesis and Antitumor Activity of New Polysubstituted Thiophenes and 1,3,4-Thiadiazoles Incorporating 2,6-Pyridine Moieties

被引：16

作者：

Ali, Korany A. ^{[1
]}

Abdalghfar, Heba S. ^{[1
]}

Mahmoud, Khaled ^{[2
]}

Ragab, Eman A. ^{[3
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt

[2] Natl Res Ctr, Dept Pharmacognosy, Cairo 12622, Egypt

[3] Cairo Univ, Dept Chem, Fac Sci, Cairo 12613, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 05期

关键词：

BIOLOGICAL EVALUATION; HETEROCYCLES; DERIVATIVES; THIAZOLE; PYRAZOLE;

D O I：

10.1002/jhet.1613

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The versatile multifunctional unreported pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (3) was prepared starting from pyridine-2,6-bis-(3-oxopropanenitrile) (1). Several new series of polysubstituted thiophenes and 1,3,4-thiadiazoles incorporating 2,6-pyridine moiety were efficiently synthesized. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines: hepatocellular liver carcinoma (HEPG2) and Caucasian breast adenocarcinoma (MCF-7). Some of the newly synthesized compounds exhibited better activity than doxorubicin as a reference drug.

引用

页码：1157 / 1164

页数：8

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