Synthesis and Antitumor Activity of New Polysubstituted Thiophenes and 1,3,4-Thiadiazoles Incorporating 2,6-Pyridine Moieties

被引：14

作者：

Ali, Korany A. ^{[1
]}

Abdalghfar, Heba S. ^{[1
]}

Mahmoud, Khaled ^{[2
]}

Ragab, Eman A. ^{[3
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt

[2] Natl Res Ctr, Dept Pharmacognosy, Cairo 12622, Egypt

[3] Cairo Univ, Dept Chem, Fac Sci, Cairo 12613, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 05期

关键词：

BIOLOGICAL EVALUATION; HETEROCYCLES; DERIVATIVES; THIAZOLE; PYRAZOLE;

D O I：

10.1002/jhet.1613

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The versatile multifunctional unreported pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (3) was prepared starting from pyridine-2,6-bis-(3-oxopropanenitrile) (1). Several new series of polysubstituted thiophenes and 1,3,4-thiadiazoles incorporating 2,6-pyridine moiety were efficiently synthesized. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines: hepatocellular liver carcinoma (HEPG2) and Caucasian breast adenocarcinoma (MCF-7). Some of the newly synthesized compounds exhibited better activity than doxorubicin as a reference drug.

引用

页码：1157 / 1164

页数：8

共 50 条

[1] Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles
Reddy, G. Mallikarjuna
Durgamma, S.
Syamaiah, K.
Yamini, G.
Padmavathi, V.
Padmaja, A.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2017, 56 (03): : 325 - 333
[2] Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles
Ergena, Asrat
Rajeshwar, Yerra
Solomon, Gebremedhin
SCIENTIFICA, 2022, 2022
[3] SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL PYRIDINE ANCHORED THIAZOLYL 1,3,4-THIADIAZOLES AND 1,2,4-TRIAZOLES
Akolkar, H. N.
Darekar, N. R.
Kundlikar, S. G.
Karale, B. K.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 25 (01) : 87 - 90
[4] Convenient synthesis and characterization of new 1,3,4-thiadiazoles and thiazoles incorporating thiophene moiety
Helmy, Mirna T.
Kamel, Monica G.
Mikhail, Madonna S.
Saleh, Fatma M.
Hassaneen, Hamdi M.
Erian, Ayman W.
Teleb, Mohamed A. Mohamed
ARKIVOC, 2024,
[5] Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent
Janowska, Sara
Khylyuk, Dmytro
Gornowicz, Agnieszka
Bielawska, Anna
Janowski, Michal
Czarnomysy, Robert
Bielawski, Krzysztof
Wujec, Monika
MOLECULES, 2022, 27 (20):
[6] Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
Sekhar, M. Madhu
Nagarjuna, U.
Padmavathi, V.
Padmaja, A.
Reddy, N. Vasudeva
Vijaya, T.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 145 : 1 - 10
[7] Synthesis and Antimicrobial Activity of New Substituted 5-(Pyridine-3-yl)-1,3,4-Thiadiazoles and Their Sugar Derivatives
El-Sayed, Wael A.
Metwally, Mohamed A.
Nada, Doaa S.
Mohamed, Asem A.
Abdel-Rahman, Adel A. -H.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (02) : 194 - 201
[8] Synthesis and Antimicrobial Activity of Some Novel Thiazoles, 1,3,4-Thiadiazines, 1,3,4-Thiadiazoles Incorporating Coumarin Moiety
Abdel-Aziem, Anhar
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (01) : 251 - 259
[9] Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazoles and 1,3,4-Thiadiazines Containing 1,2,4-Triazolo Nucleus
Purohit, Dushyant H.
Dodiya, Bhavesh L.
Ghetiya, Renish M.
Vekariya, Piyush B.
Joshi, Hitendra S.
ACTA CHIMICA SLOVENICA, 2011, 58 (01) : 53 - 59
[10] Synthesis of some new pyrazole-based 1,3-thiazoles and 1,3,4-thiadiazoles as anticancer agents
Dawood, Kamal M.
Eldebss, Taha M. A.
El-Zahabi, Heba S. A.
Yousef, Mahmoud H.
Metz, Peter
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 70 : 740 - 749

← 1 2 3 4 5 →