Admixture Mapping of Prostate Cancer in African Americans Participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP)

被引：20

作者：

Bensen, Jeannette T. ^{[1
,2
]}

Xu, Zongli ^{[3
]}

McKeigue, Paul M. ^{[4
]}

Smith, Gary J. ^{[5
]}

Fontham, Elizabeth T. H. ^{[6
]}

Mohler, James L. ^{[2
,5
,7
,8
]}

Taylor, Jack A. ^{[3
,9
]}

机构：

[1] Univ N Carolina, Dept Epidemiol, Div Urol, Chapel Hill, NC USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Div Urol, Chapel Hill, NC 27599 USA

[3] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA

[4] Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland

[5] Roswell Pk Canc Inst, Dept Urol, Buffalo, NY 14263 USA

[6] Louisiana State Univ, Sch Publ Hlth, Hlth Sci Ctr, New Orleans, LA USA

[7] SUNY Buffalo, Dept Urol, Sch Med & Biotechnol, Buffalo, NY 14260 USA

[8] Univ N Carolina, Dept Surg, Div Urol, Chapel Hill, NC USA

[9] NIEHS, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA

来源：

PROSTATE | 2014年 / 74卷 / 01期

关键词：

ancestry informative markers; prostate cancer; African American; mapping by admixture linkage disequilibrium; MALD; SNP; GENOME-WIDE ASSOCIATION; TRANSFER-RNA GENES; PROSPECTIVE IDENTIFICATION; RISK LOCUS; ANCESTRY; SUSCEPTIBILITY; VARIANTS; DESIGN; TWINS;

D O I：

10.1002/pros.22722

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUNDFew genetic risk factors have been uncovered that contribute specifically to the racial disparity in prostate cancer (CaP) observed in African Americans (AA). With the advent of ancestry informative marker (AIM) single nucleotide polymorphism (SNP) panels and powerful genetic strategies such as mapping by admixture linkage disequilibrium (MALD) it is possible to discover genes that underlie ethnic variation in disease risk. METHODSOne thousand one hundred thirty AA CaP cases enrolled in the North Carolina-Louisiana Prostate Cancer Project (PCaP) were genotyped using a 1,509 AIM SNP panel. MALD was performed using ADMIXMAP to test for linkage between CaP risk and ancestry estimates at each AIM SNP. RESULTSThe largest increase of African ancestry was observed at marker rs12543473 (P=0.0011), located on chromosome 8q24.21, and the greatest excess of European ancestry was observed at marker rs10768140 (P=0.0004) at chromosome 11p13. CONCLUSIONSThe study confirmed the 8q24 risk loci and identified a novel genomic region on 11p13 that is associated with CaP risk. These findings should be replicated in larger AA populations and combined with fine mapping data to further refine the novel 11p13 CaP risk loci. Prostate 74:1-9, 2014. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1 / 9

页数：9

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