Effects of oral deoxynivalenol exposure on immune-related parameters in lymphoid organs and serum of mice vaccinated with porcine parvovirus vaccine

被引:17
作者
Choi, Byung-Kook [1 ]
Jeong, Sang-Hee [2 ]
Cho, Joon-Hyung [1 ]
Shin, Hyo-Sook [1 ]
Son, Seong-Wan [1 ]
Yeo, Young-Keun [3 ]
Kang, Hwan-Goo [1 ]
机构
[1] Anim Plant & Fisheries Quarantine & Inspect Agcy, Toxicol & Residue Chem Div, Anyang Si 430757, Gyeonggi Do, South Korea
[2] Hoseo Univ, GLP Res Ctr, Coll Nat Sci, Asan 336795, Chungnam, South Korea
[3] Kyungpook Natl Univ, Lipid Chem Lab, Taegu 702701, South Korea
关键词
Deoxynivalenol; C3H mouse; Immune parameters; Cytokines; Immunoglobulin; B6C3F1; MOUSE; T-2; TOXIN; MYCOTOXINS; VOMITOXIN; FEED; ZEARALENONE; DON; MODULATION; MECHANISMS; INGESTION;
D O I
10.1007/s12550-013-0161-3
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Mice were exposed to deoxynivalenol (DON) via drinking water at a concentration of 2 mg/L for 36 days. On day 8 of treatment, inactivated porcine parvovirus vaccine (PPV) was injected intraperitoneally. The relative and absolute weight of the spleen was significantly decreased in the DON-treated group (DON). Antibody titers to parvovirus in serum were 47.9 +/- 2.4 in the vaccination group (Vac), but 15.2 +/- 6.5 in the group treated with DON and vaccine (DON+Vac). The IgA and IgG was not different in the DON, Vac an,d DON+Vac groups. IgM was significantly lower only in the DON+Vac group. However IgE was significantly increased in the Vac and DON+Vac group, but no change was observed between the Vac and DON+Vac groups. The concentrations of IL-2, IL-4, GM-CSF, MCP-1 and Rantes in serum, and IL-1 alpha in mesenteric lymph node and MIP-1 beta in spleen were significantly increased by DON treatment compared to control. The concentrations of IL-2, IL-5, IL-6, IL-9, IL-12, IL-13 and Rantes in thymus, of IL-2 in spleen, and of IL-1 alpha, IL-1 beta, IL-3, IL-5, IL-10, IL-17, G-CSF, GM-CSF and MCP-1 in mesenteric lymph nodes were significantly decreased in mice compared to those in the Vac group, while concentrations of IL-1 alpha, IL-2, IL-9, IL-13, G-CSF, GM-CSF, IFN-gamma, MCP-1, MIP-1 alpha and TNF-alpha were significantly increased in serum compared to the Vac group. In conclusion, the results presented here indicate that exposure to DON at 2.0 mg/L via drinking water can disrupt the immune response in vaccinated mice by modulating cytokines and chemokines involved in their immune response to infectious disease.
引用
收藏
页码:185 / 192
页数:8
相关论文
共 44 条
[31]   Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox [J].
Pestka, JJ ;
Zhou, HR ;
Moon, Y ;
Chung, YJ .
TOXICOLOGY LETTERS, 2004, 153 (01) :61-73
[32]   PROGRESSIVE SERUM IGE ELEVATION IN THE B6C3F1 MOUSE FOLLOWING WITHDRAWAL OF DIETARY VOMITOXIN (DEOXYNIVALENOL) [J].
PESTKA, JJ ;
DONG, W .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1994, 22 (02) :314-316
[33]   Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses [J].
Pinton, Philippe ;
Accensi, Francesc ;
Beauchamp, Erwan ;
Cossalter, Anne-Marie ;
Callu, Patrick ;
Grosjean, Francois ;
Oswald, Isabelle P. .
TOXICOLOGY LETTERS, 2008, 177 (03) :215-222
[34]   DEOXYNIVALENOL-CONTAMINATED WHEAT IN SWINE DIETS [J].
POLLMANN, DS ;
KOCH, BA ;
SEITZ, LM ;
MOHR, HE ;
KENNEDY, GA .
JOURNAL OF ANIMAL SCIENCE, 1985, 60 (01) :239-247
[35]  
Prelusky Dan B., 1994, Natural Toxins, V2, P97, DOI 10.1002/nt.2620020302
[36]   Toxicology of deoxynivalenol (vomitoxin) [J].
Rotter, BA ;
Prelusky, DB ;
Pestka, JJ .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1996, 48 (01) :1-34
[37]   Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states" -: Subtask:: trichothecenes [J].
Schothorst, RC ;
van Egmond, HP .
TOXICOLOGY LETTERS, 2004, 153 (01) :133-143
[38]  
Sobrova Pavlina, 2010, Interdiscip Toxicol, V3, P94, DOI 10.2478/v10102-010-0019-x
[39]   METABOLISM OF 3 TRICHOTHECENE MYCOTOXINS, T-2 TOXIN, DIACETOXYSCIRPENOL AND DEOXYNIVALENOL, BY BOVINE RUMEN MICROORGANISMS [J].
SWANSON, SP ;
NICOLETTI, J ;
ROOD, HD ;
BUCK, WB ;
COTE, LM ;
YOSHIZAWA, T .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 414 (02) :335-342
[40]   Mycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs [J].
Taranu, I ;
Marin, DE ;
Bouhet, S ;
Pascale, F ;
Bailly, JD ;
Miller, JD ;
Pinton, P ;
Oswald, IP .
TOXICOLOGICAL SCIENCES, 2005, 84 (02) :301-307