Mediator Lipidomics in Ophthalmology: Targets for Modulation in Inflammation, Neuroprotection and Nerve Regeneration

被引：36
作者：
Gordon, William C.
Bazan, Nicolas G. [1 ,2 ]
机构：
[1] Louisiana State Univ, Neurosci Ctr Excellence, Hlth Sci Ctr, New Orleans, LA USA
[2] Louisiana State Univ, Dept Ophthalmol, Sch Med, Hlth Sci Ctr, New Orleans, LA USA
来源：
CURRENT EYE RESEARCH | 2013年 / 38卷 / 10期
基金：
美国国家卫生研究院;
关键词：
Cornea; docosahexaenoic acid; docosanoids; lipid mediators; neuroprotectin D1; PIGMENT EPITHELIAL-CELLS; POLYUNSATURATED FATTY-ACID; DOCOSAHEXAENOIC ACID; PHOTORECEPTOR CELLS; RESOLVIN D1; RETINA; DEGENERATION; RESOLUTION; SURVIVAL; ELOVL4;
D O I：
10.3109/02713683.2013.827211
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Studies in the central nervous system (CNS) and retina have revealed the significance of docosahexaenoic acid (DHA), an essential omega-3, 22 carbon 6 double bond (22:6), fatty acid. DHA is necessary for various functions in the CNS, including neuronal membrane bio- and synaptogenesis in memory and vision, and it is the precursor for docosanoids and neuroprotectin D1 (NPD1; 10R, 17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z hexaenoic acid), a DHA bio-derivative with neuroprotective properties. This review covers three targets in ophthalmology for mediator lipidomics, a subgroup within the field of metabolomics: inflammation, neuroprotection and nerve regeneration. It also discusses the role DHA, NPD1 and other lipid mediators play in these three areas.
引用
收藏
页码：995 / 1005
页数：11
相关论文
共 72 条
[71]   Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration [J].
Vasireddy, Vidyullatha ;
Jablonski, Monica M. ;
Mandal, Md Nawajes A. ;
Raz-Prag, Dorit ;
Wang, Xiaofei F. ;
Nizol, Lesli ;
Iannaccone, Alessandro ;
Musch, David C. ;
Bush, Ronald A. ;
Salem, Norman, Jr. ;
Sieving, Paul A. ;
Ayyagari, Radha .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (10) :4558-4568
[72]  
Zhao YH, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0015816, 10.1371/journal.pone.0016470]
12345678