Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural-like cells

被引：49

作者：

Esmaeili, Elaheh ^{[1
,2
]}

Soleimani, Masoud ^{[2
]}

Ghiass, Mohammad Adel ^{[3
]}

Hatamie, Shadie ^{[1
]}

Vakilian, Saeed ^{[1
]}

Zomorrod, Mahsa Soufi ^{[1
]}

Sadeghzadeh, Negar ^{[1
]}

Vossoughi, Manouchehr ^{[4
,5
]}

Hosseinzadeh, Simzar ^{[6
]}

机构：

[1] Stem Cell Technol Res Ctr, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Hematol & Cell Therapy, Fac Med Sci, Tehran 1411713116, Iran

[3] Tarbiat Modares Univ, Dept Tissue Engn, Fac Med Sci, Tehran, Iran

[4] Sharif Univ Technol, Inst Nanosci & Nanotechnol, Tehran, Iran

[5] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran 1985717443, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 08期

关键词：

electrospinning; magnetoelectric; mesenchymal stem cells; neural differentiation; scaffold; POLY(VINYLIDENE FLUORIDE); BETA-PHASE; DRUG-DELIVERY; DISPERSION; TRANSFORMATION; POLYMORPHISM; SURFACES; FILMS;

D O I：

10.1002/jcp.28040

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive filler, CoFe2O (4) nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through a hydrothermal process. After that, the piezoelectric PVDF polymer, which contained the magnetic nanoparticles, underwent the electrospun process to form ME nanofibers, the ME property of which has the potential to be used in areas such as tissue engineering, biosensors, and actuators.

引用

页码：13617 / 13628

页数：12

共 58 条

[1] Predicting force output of trilayer polymer actuators [J].