Effects of Maternal Immune System Status on Neonate's Immune System

被引：0
作者：
Khosravi, Mohammad [1 ]
Khazaeel, Kaveh [2 ]
Mahabady, Mahmood Khaksary [2 ,3 ]
Behmanesh, Mohammad Amin [4 ]
机构：
[1] Shahid Chamran Univ Ahvaz, Fac Vet Med, Dept Pathobiol, Ahvaz, Iran
[2] Shahid Chamran Univ Ahvaz, Fac Vet Med, Dept Basic Sci, Ahvaz, Iran
[3] Kashan Univ Med Sci, Anat Sci Res Ctr, Inst Basic Sci, Kashan, Iran
[4] Dezful Univ Med Sci, Fac Med, Dept Histol, Dezful, Iran
来源：
IRANIAN JOURNAL OF NEONATOLOGY | 2020年 / 11卷 / 03期
关键词：
Immune response; Maternal; Neonate; Rat; PRENATAL STRESS; PREGNANCY; STIMULATION; CYTOKINES; LEUKOCYTES; BRAIN; ALPHA; CELLS; IL-4; LIVE;
D O I：
10.22038/ijn.2020.41505.1682
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate's immune system. Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate's humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study. Results: The spleen's mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P <= 0.05) in the anti-sheep red blood cells antibody titer. Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate's immune responses, spleen, liver, and thymus development.
引用
收藏
页码：31 / 37
页数：7
相关论文
共 39 条
[1]   TNF-α and the Development of the Neonatal Immune System: Implications for Inhibitor Use in Pregnancy [J].
Arsenescu, Razvan ;
Arsenescu, Violeta ;
de Villiers, Willem J. S. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (04) :559-562
[2]   Maternal lipopolysaccharide-induced inflammation during pregnancy programs impaired offspring innate immune responses [J].
Beloosesky, Ron ;
Maravi, Nir ;
Weiner, Zeev ;
Khatib, Nizar ;
Awad, Nibal ;
Boles, Julie ;
Ross, Michael G. ;
Itskovitz-Eldor, Joseph .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2010, 203 (02) :185.e1-185.e4
[3]   The immune system and developmental programming of brain and behavior [J].
Bilbo, Staci D. ;
Schwarz, Jaclyn M. .
FRONTIERS IN NEUROENDOCRINOLOGY, 2012, 33 (03) :267-286
[4]   Serologic-evidence of prenatal influenza in the etiology of schizophrenia [J].
Brown, AS ;
Begg, MD ;
Gravenstein, S ;
Schaefer, CA ;
Wyatt, RJ ;
Bresnahan, M ;
Babulas, VP ;
Susser, ES .
ARCHIVES OF GENERAL PSYCHIATRY, 2004, 61 (08) :774-780
[5]   Immune Influence on Adult Neural Stem Cell Regulation and Function [J].
Carpentier, Pamela A. ;
Palmer, Theo D. .
NEURON, 2009, 64 (01) :79-92
[6]   Prenatal stress diminishes the cytokine response of leukocytes to endotoxin stimulation in juvenile rhesus monkeys [J].
Coe, CL ;
Kramer, M ;
Kirschbaum, C ;
Netter, P ;
Fuchs, E .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (02) :675-681
[7]   LIFE AND DEATH BY P53 [J].
ELLEDGE, RM ;
LEE, WH .
BIOESSAYS, 1995, 17 (11) :923-930
[8]   IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13 [J].
Fallon, PG ;
Jolin, HE ;
Smith, P ;
Emson, CL ;
Townsend, MJ ;
Fallon, R ;
Smith, P ;
McKenzie, ANJ .
IMMUNITY, 2002, 17 (01) :7-17
[9]   Immune cells in term and preterm labor [J].
Gomez-Lopez, Nardhy ;
StLouis, Derek ;
Lehr, Marcus A. ;
Sanchez-Rodriguez, Elly N. ;
Arenas-Hernandez, Marcia .
CELLULAR & MOLECULAR IMMUNOLOGY, 2014, 11 (06) :571-581
[10]  
Hodgson E, 1998, DICT TOXICOLOGY, P450
1234