Serotype Distribution and Antimicrobial Resistance of Invasive S. pneumoniae among Indian Children before the Introduction of Pneumococcal Conjugate Vaccine

被引：5
作者：
Ganaie, Feroze [1 ]
Govindan, Vandana [1 ]
Nagraj, Geetha [1 ]
Ravikumar, K. L. [1 ]
机构：
[1] Hosp & Res Ctr, Kempegowda Inst Med Sci, Dept Microbiol, Cent Res Lab, KR Rd, Bangalore 560004, Karnataka, India
来源：
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES | 2016年 / 11卷 / 04期
关键词：
invasive pneumococcal disease; serotyping; antimicrobial resistance; STREPTOCOCCUS-PNEUMONIAE; ANTIBIOTIC-RESISTANCE; HIGH PREVALENCE; DISEASE; INFECTIONS; SURVEILLANCE; BANGLADESH; CARRIAGE; TRENDS; 19A;
D O I：
10.1055/s-0036-1597650
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study was conducted to provide current information on serotype distribution and drug resistance patterns of invasive Streptococcus pneumoniae among children. Sterile site samples from 1,504 children 5 years, who were clinically and radiologically suspected of having invasive pneumococcal infection were evaluated. The leading serotypes causing invasive pneumococcal disease (IPD) were 1, 6B, and 14. High-level penicillin resistance was observed in 11% of isolates belonging to serotypes 6B, 1, and 5. Multidrug resistance was observed in 24% of strains. Our results reveal that PCV-10 and PCV-13 vaccines can protect against 68% and 78% of IPD serotypes, respectively.
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收藏
页码：118 / 125
页数：8
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