Serotype Distribution and Antimicrobial Resistance of Invasive S. pneumoniae among Indian Children before the Introduction of Pneumococcal Conjugate Vaccine

被引：5

作者：

Ganaie, Feroze ^{[1
]}

Govindan, Vandana ^{[1
]}

Nagraj, Geetha ^{[1
]}

Ravikumar, K. L. ^{[1
]}

机构：

[1] Hosp & Res Ctr, Kempegowda Inst Med Sci, Dept Microbiol, Cent Res Lab, KR Rd, Bangalore 560004, Karnataka, India

来源：

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES | 2016年 / 11卷 / 04期

关键词：

invasive pneumococcal disease; serotyping; antimicrobial resistance; STREPTOCOCCUS-PNEUMONIAE; ANTIBIOTIC-RESISTANCE; HIGH PREVALENCE; DISEASE; INFECTIONS; SURVEILLANCE; BANGLADESH; CARRIAGE; TRENDS; 19A;

D O I：

10.1055/s-0036-1597650

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study was conducted to provide current information on serotype distribution and drug resistance patterns of invasive Streptococcus pneumoniae among children. Sterile site samples from 1,504 children 5 years, who were clinically and radiologically suspected of having invasive pneumococcal infection were evaluated. The leading serotypes causing invasive pneumococcal disease (IPD) were 1, 6B, and 14. High-level penicillin resistance was observed in 11% of isolates belonging to serotypes 6B, 1, and 5. Multidrug resistance was observed in 24% of strains. Our results reveal that PCV-10 and PCV-13 vaccines can protect against 68% and 78% of IPD serotypes, respectively.

引用

页码：118 / 125

页数：8

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