Bioactive natural products from the genus Salinospora: a review

被引：10
|
作者：
Kim, Haerin [1 ]
Kim, Sohee [1 ]
Kim, Minju [1 ]
Lee, Chaeyoung [1 ]
Yang, Inho [2 ]
Nam, Sang-Jip [3 ]
机构：
[1] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea
[2] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Pusan 49112, South Korea
[3] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2020年 / 43卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
Salinispora; Marine natural products; Actinomycetes; Salinispora arenicola; Salinispora tropica; Salinispora pacifica; MARINE BACTERIUM; A-C; SECONDARY METABOLITE; PROTEASOME INHIBITOR; BIOLOGICAL-ACTIVITY; DESFERRIOXAMINE E; CYCLIC-PEPTIDES; SALINISPORA; BIOSYNTHESIS; GENOME;
D O I：
10.1007/s12272-020-01288-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Actinomycetes are an important source for bioactive secondary metabolites. Among them, the genus Salinispora is one of the first salt obligatory marine species worldwide and is typically found in various types of substrates in tropical and subtropical marine environments including sediments and marine organisms. This genus produces a wide range of chemical scaffolds and bioactive compounds such as lomaiviticins, cyclomarins, rifamycins, salinaphthoquinones, and salinosporamides. This review arranged Salinispora derived secondary metabolites according to the three species that comprise the genus. Moreover, muta- and semi-synthesis analogs derived from salinosporamide were also described in this review.
引用
收藏
页码：1230 / 1258
页数：29
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