Protein S-sulfhydration by hydrogen sulfide in cardiovascular system

被引:94
作者
Meng, Guoliang [1 ,2 ]
Zhao, Shuang [3 ]
Xie, Liping [3 ]
Han, Yi [4 ]
Ji, Yong [2 ,3 ]
机构
[1] Nantong Univ, Sch Pharm, Dept Pharmacol, Nantong, Peoples R China
[2] Nanjing Med Univ, Sch Pharm, Key Lab Cardiovasc & Cerebrovasc Med, 101 Longmian Rd, Nanjing 211166, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Dept Geriatr, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
CYSTATHIONINE GAMMA-LYASE; TYROSINE-PHOSPHATASE; 1B; TAG-SWITCH METHOD; CONCISE GUIDE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; PHARMACOLOGY; APOPTOSIS; CELL; H2S;
D O I
10.1111/bph.13825
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hydrogen sulfide (H2S), independently of any specific transporters, has a number of biological effects on the cardiovascular system. However, until now, the detailed mechanism of H2S was not clear. Recently, a novel post-translational modification induced by H2S, named S-sulfhydration, has been proposed. S-sulfhydration is the chemical modification of specific cysteine residues of target proteins by H2S. There are several methods for detecting S-sulfhydration, such as the modified biotin switch assay, maleimide assay with fluorescent thiol modifying regents, tag-switch method and mass spectrometry. H2S induces S-sulfhydration on enzymes or receptors (such as p66Shc, phospholamban, protein tyrosine phosphatase 1B, mitogen-activated extracellular signal-regulated kinase 1 and ATP synthase subunit ), transcription factors (such as specific protein-1, kelch-like ECH-associating protein 1, NF-B and interferon regulatory factor-1), and ion channels (such as voltage-activated Ca2+ channels, transient receptor potential channels and ATP-sensitive K+ channels) in the cardiovascular system. Although significant progress has been achieved in delineating the role of protein S-sulfhydration by H2S in the cardiovascular system, more proteins with detailed cysteine sites of S-sulfhydration as well as physiological function need to be investigated in further studies. This review mainly summarizes the role and possible mechanism of S-sulfhydration in the cardiovascular system. The S-sulfhydrated proteins may be potential novel targets for therapeutic intervention and drug design in the cardiovascular system, which may accelerate the development and application of H2S-related drugs in the future. Linked ArticlesThis article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc
引用
收藏
页码:1146 / 1156
页数:11
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