Protein S-sulfhydration by hydrogen sulfide in cardiovascular system

被引：94

作者：

Meng, Guoliang ^{[1
,2
]}

Zhao, Shuang ^{[3
]}

Xie, Liping ^{[3
]}

Han, Yi ^{[4
]}

Ji, Yong ^{[2
,3
]}

机构：

[1] Nantong Univ, Sch Pharm, Dept Pharmacol, Nantong, Peoples R China

[2] Nanjing Med Univ, Sch Pharm, Key Lab Cardiovasc & Cerebrovasc Med, 101 Longmian Rd, Nanjing 211166, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Dept Geriatr, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2018年 / 175卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CYSTATHIONINE GAMMA-LYASE; TYROSINE-PHOSPHATASE; 1B; TAG-SWITCH METHOD; CONCISE GUIDE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; PHARMACOLOGY; APOPTOSIS; CELL; H2S;

D O I：

10.1111/bph.13825

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrogen sulfide (H2S), independently of any specific transporters, has a number of biological effects on the cardiovascular system. However, until now, the detailed mechanism of H2S was not clear. Recently, a novel post-translational modification induced by H2S, named S-sulfhydration, has been proposed. S-sulfhydration is the chemical modification of specific cysteine residues of target proteins by H2S. There are several methods for detecting S-sulfhydration, such as the modified biotin switch assay, maleimide assay with fluorescent thiol modifying regents, tag-switch method and mass spectrometry. H2S induces S-sulfhydration on enzymes or receptors (such as p66Shc, phospholamban, protein tyrosine phosphatase 1B, mitogen-activated extracellular signal-regulated kinase 1 and ATP synthase subunit ), transcription factors (such as specific protein-1, kelch-like ECH-associating protein 1, NF-B and interferon regulatory factor-1), and ion channels (such as voltage-activated Ca2+ channels, transient receptor potential channels and ATP-sensitive K+ channels) in the cardiovascular system. Although significant progress has been achieved in delineating the role of protein S-sulfhydration by H2S in the cardiovascular system, more proteins with detailed cysteine sites of S-sulfhydration as well as physiological function need to be investigated in further studies. This review mainly summarizes the role and possible mechanism of S-sulfhydration in the cardiovascular system. The S-sulfhydrated proteins may be potential novel targets for therapeutic intervention and drug design in the cardiovascular system, which may accelerate the development and application of H2S-related drugs in the future. Linked ArticlesThis article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc

引用

页码：1146 / 1156

页数：11

共 86 条

[1] Cell signaling mediated by nitrated cyclic guanine nucleotide [J].

Akaike, Takaaki ;

Fujii, Shigemoto ;

Sawa, Tomohiro ;

Ihara, Hideshi .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 23 (03) :166-174

[2] THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Voltage-gated ion channels [J].

Alexander, Stephen P. H. ;

Catterall, William A. ;

Kelly, Eamonn ;

Marrion, Neil ;

Peters, John A. ;

Benson, Helen E. ;

Faccenda, Elena ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. ;

Aldrich, R. ;

Attali, B. ;

Back, M. ;

Barnes, N. M. ;

Bathgate, R. ;

Beart, P. M. ;

Becirovic, E. ;

Biel, M. ;

Birdsall, N. J. ;

Boison, D. ;

Brauner-Osborne, H. ;

Broeer, S. ;

Bryant, C. ;

Burnstock, G. ;

Burris, T. ;

Cain, D. ;

Calo, G. ;

Chan, S. L. ;

Chandy, K. G. ;

Chiang, N. ;

Christakos, S. ;

Christopoulos, A. ;

Chun, J. J. ;

Chung, J. -J. ;

Clapham, D. E. ;

Connor, M. A. ;

Coons, L. ;

Cox, H. M. ;

Dautzenberg, F. M. ;

Dent, G. ;

Douglas, S. D. ;

Dubocovich, M. L. ;

Edwards, D. P. ;

Farndale, R. ;

Fong, T. M. ;

Forrest, D. ;

Fowler, C. J. ;

Fuller, P. ;

Gainetdinov, R. R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (24) :5904-5941

[3] THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Enzymes [J].

Alexander, Stephen P. H. ;

Fabbro, Doriano ;

Kelly, Eamonn ;

Marrion, Neil ;

Peters, John A. ;

Benson, Helen E. ;

Faccenda, Elena ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. ;

Aldrich, R. ;

Attali, B. ;

Back, M. ;

Barnes, N. M. ;

Bathgate, R. ;

Beart, P. M. ;

Becirovic, E. ;

Biel, M. ;

Birdsall, N. J. ;

Boison, D. ;

Brauner-Osborne, H. ;

Broeer, S. ;

Bryant, C. ;

Burnstock, G. ;

Burris, T. ;

Cain, D. ;

Calo, G. ;

Chan, S. L. ;

Chandy, K. G. ;

Chiang, N. ;

Christakos, S. ;

Christopoulos, A. ;

Chun, J. J. ;

Chung, J. -J. ;

Clapham, D. E. ;

Connor, M. A. ;

Coons, L. ;

Cox, H. M. ;

Dautzenberg, F. M. ;

Dent, G. ;

Douglas, S. D. ;

Dubocovich, M. L. ;

Edwards, D. P. ;

Farndale, R. ;

Fong, T. M. ;

Forrest, D. ;

Fowler, C. J. ;

Fuller, P. ;

Gainetdinov, R. R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (24) :6024-6109

[4] THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Nuclear hormone receptors [J].

Alexander, Stephen P. H. ;

Cidlowski, John A. ;

Kelly, Eamonn ;

Marrion, Neil ;

Peters, John A. ;

Benson, Helen E. ;

Faccenda, Elena ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. ;

Aldrich, R. ;

Attali, B. ;

Back, M. ;

Barnes, N. M. ;

Bathgate, R. ;

Beart, P. M. ;

Becirovic, E. ;

Biel, M. ;

Birdsall, N. J. ;

Boison, D. ;

Brauner-Osborne, H. ;

Broeer, S. ;

Bryant, C. ;

Burnstock, G. ;

Burris, T. ;

Cain, D. ;

Calo, G. ;

Chan, S. L. ;

Chandy, K. G. ;

Chiang, N. ;

Christakos, S. ;

Christopoulos, A. ;

Chun, J. J. ;

Chung, J. -J. ;

Clapham, D. E. ;

Connor, M. A. ;

Coons, L. ;

Cox, H. M. ;

Dautzenberg, F. M. ;

Dent, G. ;

Douglas, S. D. ;

Dubocovich, M. L. ;

Edwards, D. P. ;

Farndale, R. ;

Fong, T. M. ;

Forrest, D. ;

Fowler, C. J. ;

Fuller, P. ;

Gainetdinov, R. R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (24) :5956-5978

[5] THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Catalytic receptors [J].

Alexander, Stephen P. H. ;

Fabbro, Doriano ;

Kelly, Eamonn ;

Marrion, Neil ;

Peters, John A. ;

Benson, Helen E. ;

Faccenda, Elena ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. ;

Aldrich, R. ;

Attali, B. ;

Back, M. ;

Barnes, N. M. ;

Bathgate, R. ;

Beart, P. M. ;

Becirovic, E. ;

Biel, M. ;

Birdsall, N. J. ;

Boison, D. ;

Brauner-Osborne, H. ;

Broeer, S. ;

Bryant, C. ;

Burnstock, G. ;

Burris, T. ;

Cain, D. ;

Calo, G. ;

Chan, S. L. ;

Chandy, K. G. ;

Chiang, N. ;

Christakos, S. ;

Christopoulos, A. ;

Chun, J. J. ;

Chung, J. -J. ;

Clapham, D. E. ;

Connor, M. A. ;

Coons, L. ;

Cox, H. M. ;

Dautzenberg, F. M. ;

Dent, G. ;

Douglas, S. D. ;

Dubocovich, M. L. ;

Edwards, D. P. ;

Farndale, R. ;

Fong, T. M. ;

Forrest, D. ;

Fowler, C. J. ;

Fuller, P. ;

Gainetdinov, R. R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (24) :5979-6023

[6] THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Overview [J].

Alexander, Stephen P. H. ;

Kelly, Eamonn ;

Marrion, Neil ;

Peters, John A. ;

Benson, Helen E. ;

Faccenda, Elena ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Buneman, O. Peter ;

Catterall, William A. ;

Cidlowski, John A. ;

Davenport, Anthony P. ;

Fabbro, Doriano ;

Fan, Grace ;

McGrath, John C. ;

Spedding, Michael ;

Davies, Jamie A. ;

Aldrich, R. ;

Attali, B. ;

Back, M. ;

Barnes, N. M. ;

Bathgate, R. ;

Beart, P. M. ;

Becirovic, E. ;

Biel, M. ;

Birdsall, N. J. ;

Boison, D. ;

Brauner-Osborne, H. ;

Broeer, S. ;

Bryant, C. ;

Burnstock, G. ;

Burris, T. ;

Cain, D. ;

Calo, G. ;

Chan, S. L. ;

Chandy, K. G. ;

Chiang, N. ;

Christakos, S. ;

Christopoulos, A. ;

Chun, J. J. ;

Chung, J. -J. ;

Clapham, D. E. ;

Connor, M. A. ;

Coons, L. ;

Cox, H. M. ;

Dautzenberg, F. M. ;

Dent, G. ;

Douglas, S. D. ;

Dubocovich, M. L. .

BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (24) :5729-5743

[7] The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide [J].

Altaany, Zaid ;

Ju, YoungJun ;

Yang, Guangdong ;

Wang, Rui .

SCIENCE SIGNALING, 2014, 7 (342)

[8] Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes [J].

Cai, Junyan ;

Shi, Xiaoqin ;

Wang, Huamin ;

Fan, Jinghui ;

Feng, Yongliang ;

Lin, Xianjuan ;

Yang, Jichun ;

Cui, Qinghua ;

Tang, Chaoshu ;

Xu, Guoheng ;

Geng, Bin .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2016, 1861 (05) :419-429

[9] The Role of Hydrogen Sulfide in Renal System [J].

Cao, Xu ;

Bian, Jin-Song .

FRONTIERS IN PHARMACOLOGY, 2016, 7

[10] Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism [J].

Chen, Lian-Yun ;

Chen, Qin ;

Zhu, Xiao-Jing ;

Kong, De-Song ;

Wu, Li ;

Shao, Jiang-juan ;

Zheng, Shi-Zhong .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 36 :23-30

← 1 2 3 4 5 6 7 8 9 →