Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability

被引：131

作者：

Zhang, Yanfeng ^{[1
]}

Yin, Qian ^{[1
]}

Yin, Lichen ^{[1
]}

Ma, Liang ^{[1
]}

Tang, Li ^{[1
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 25期

基金：

美国国家科学基金会;

关键词：

cancer therapy; controlled release; polymer-drug conjugate; polymers; trigger-responsive polymer; RING-OPENING POLYMERIZATION; HPMA COPOLYMER; CONJUGATE NANOPARTICLES; DOXORUBICIN CONJUGATE; CANCER-CELLS; DELIVERY; ANTICANCER; NANOMEDICINES; CAMPTOTHECIN; FORMULATION;

D O I：

10.1002/anie.201300497

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6435 / 6439

页数：5

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