Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability

被引：130
|
作者：
Zhang, Yanfeng [1 ]
Yin, Qian [1 ]
Yin, Lichen [1 ]
Ma, Liang [1 ]
Tang, Li [1 ]
Cheng, Jianjun [1 ]
机构：
[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 25期
基金：
美国国家科学基金会;
关键词：
cancer therapy; controlled release; polymer-drug conjugate; polymers; trigger-responsive polymer; RING-OPENING POLYMERIZATION; HPMA COPOLYMER; CONJUGATE NANOPARTICLES; DOXORUBICIN CONJUGATE; CANCER-CELLS; DELIVERY; ANTICANCER; NANOMEDICINES; CAMPTOTHECIN; FORMULATION;
D O I：
10.1002/anie.201300497
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6435 / 6439
页数：5
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