Recent Advances in 18F Radiochemistry: A Focus on B-18F, Si-18F, Al-18F, and C-18F Radiofluorination via Spirocyclic Iodonium Ylides

被引：48

作者：

Bernard-Gauthier, Vadim ^{[1
,2
]}

Lepage, Mathieu L. ^{[3
]}

Waengler, Bjoern ^{[4
]}

Bailey, Justin J. ^{[5
]}

Liang, Steven H. ^{[1
,2
]}

Perrin, David M. ^{[3
]}

Vasdev, Neil ^{[1
,2
]}

Schirrmacher, Ralf ^{[5
]}

机构：

[1] Massachusetts Gen Hosp, Div Nucl Med & Mol Imaging, Boston, MA 02114 USA

[2] Harvard Med Sch, Dept Radiol, Boston, MA USA

[3] Univ British Columbia, Chem Dept, Vancouver, BC, Canada

[4] Heidelberg Univ, Med Fac Mannheim, Dept Clin Radiol & Nucl Med, Mol Imaging & Radiochem, Mannheim, Germany

[5] Univ Alberta, Div Oncol Imaging, Dept Oncol, Edmonton, AB, Canada

来源：

JOURNAL OF NUCLEAR MEDICINE | 2018年 / 59卷 / 04期

关键词：

radiochemistry; fluorine-18; radiofluorination; spirocyclic iodonium; IN-VIVO EVALUATION; ONE-STEP; CONCURRENT CHEMORADIOTHERAPY; IMAGING AGENTS; PET/CT; F-18-ALFATIDE; TUMORS; ORGANOTRIFLUOROBORATE; RADIOSYNTHESIS; SOLVOLYSIS;

D O I：

10.2967/jnumed.117.197095

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Straightforward radiosynthesis protocols for F-18-labeled radio-pharmaceuticals are an indispensable but often overlooked prerequisite to successfully perform molecular imaging studies in vivo by PET. In recent years, thanks to the expansion of the F-18 chemical toolbox, structurally diverse and novel clinically relevant radiopharmaceuticals have been synthesized with both high efficiency and ready implementation. This article provides an overview of recent F-18-labeling methodologies, specifically for B-F-18, Si-F-18, Al-F-18, and iodine (III)-mediated radio-fluorination via the spirocyclic iodonium ylide technology.

引用

页码：568 / 572

页数：5

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