Algorithm proposal based on the C. Diff Quik Chek Complete ICT device for detecting Clostridium difficile infection

被引：17
|
作者：
Angeles Orellana-Miguel, Ma [1 ]
Alcolea-Medina, Adela [1 ]
Barrado-Blanco, Laura [1 ]
Rodriguez-Otero, Joaquin [1 ]
Chaves-Sanchez, Fernando [1 ]
机构：
[1] Hosp Univ 12 Octubre, Microbiol Serv, Madrid, Spain
来源：
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2013年 / 31卷 / 02期
关键词：
Clostridium difficile infection; Nosocomial diarrhoea; Toxigenic Clostridium difficile; GLUTAMATE-DEHYDROGENASE; TOXIN; DIAGNOSIS; ASSAY; CULTURE; SOCIETY; TESTS;
D O I：
10.1016/j.eimc.2012.01.003
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objective: To assess a new immunochromatography (ICT) test that detects glutamate dehydrogenase (GDH) antigen and Clostridium difficile toxin A/B simultaneously, and to propose an algorithm for the diagnosis of C difficile infection (CDI) based on this test. Methods: We analysed 970 stool samples. Discrepant results between GDH and toxin A/B were resolved using toxigenic culture as the reference. Results: This test enabled us to obtain a conclusive result in <30 min in 93.8% of the samples. Among the discrepant results (GDH (+)/Toxin A/B (-)), 41.7% (25/60) were found to be toxigenic C dfficile by toxigenic culture. Conclusion: This test has a high sensitivity and specificity for the diagnosis of CDI. (C) 2011 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：97 / 99
页数：3
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