Does Kidney Disease Cause Hypertension?

被引:10
作者
Peixoto, Aldo J. [1 ,2 ,4 ]
Orias, Marcelo [3 ]
Desir, Gary V. [1 ,2 ]
机构
[1] VA Connecticut Healthcare Syst, Med Serv, West Haven, CT USA
[2] Yale Univ, Sch Med, Dept Internal Med, Nephrol Sect, New Haven, CT 06510 USA
[3] Sanat Allende, Serv Nephrol, Cordoba, Argentina
[4] Med Serv 111, West Haven, CT 06516 USA
关键词
Hypertension; Chronic kidney disease; CKD; Kidney failure; Renal function; Proteinuria; Albuminuria; Polycystic kidney disease; Hematuria; BASEMENT-MEMBRANE DISEASE; RENIN-ANGIOTENSIN SYSTEM; BLOOD-PRESSURE CONTROL; SIMPLE RENAL CYST; REMNANT KIDNEY; NORMAL RANGE; RISK; MICROALBUMINURIA; LONG; ALBUMINURIA;
D O I
10.1007/s11906-013-0327-6
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Hypertension complicates most cases of chronic kidney disease. While the prevalence and severity of hypertension increase as glomerular filtration rate falls, hypertension is often observed in patients with structural kidney disease while renal function is normal, in particular those with polycystic kidney disease or proteinuric glomerular diseases. On the other hand, even severe reductions in renal function may not result in hypertension, especially if there is effective control of extracellular fluid volume. Recent clinical and experimental data indicate that proteinuria may mediate sodium retention and hypertension via plasmin-mediated activation of the epithelial sodium channel. Current evidence supports the notion that chronic kidney disease is a cause of chronic hypertension, even in the absence of detectable changes in glomerular filtration rate.
引用
收藏
页码:89 / 94
页数:6
相关论文
共 57 条
[1]  
ADAMS LG, 1994, LAB INVEST, V70, P347
[2]   GFR, proteinuria and circadian blood pressure [J].
Agarwal, Rajiv ;
Light, Robert P. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (08) :2400-2406
[3]  
[Anonymous], BRENNER RECTORS KIDN
[4]  
[Anonymous], AM J PHYSL HEART CIR
[5]  
[Anonymous], UROLOGY
[6]  
[Anonymous], ACTA PHYSL OXF
[7]   ABSENCE OF GLOMERULAR INJURY OR NEPHRON LOSS IN A NORMOTENSIVE RAT REMNANT KIDNEY MODEL [J].
BIDANI, AK ;
MITCHELL, KD ;
SCHWARTZ, MM ;
NAVAR, LG ;
LEWIS, EJ .
KIDNEY INTERNATIONAL, 1990, 38 (01) :28-38
[8]   MICROALBUMINURIA IN SALT-SENSITIVE PATIENTS - A MARKER FOR RENAL AND CARDIOVASCULAR RISK-FACTORS [J].
BIGAZZI, R ;
BIANCHI, S ;
BALDARI, D ;
SGHERRI, G ;
BALDARI, G ;
CAMPESE, VM .
HYPERTENSION, 1994, 23 (02) :195-199
[9]   Meta-analysis: Risk for hypertension in living kidney donors [J].
Boudville, Neil ;
Prasad, G. V. Ramesh ;
Knoll, Greg ;
Muirhead, Norman ;
Thiessen-Philbrook, Heather ;
Yang, Robert C. ;
Rosas-Arellano, M. Patricia ;
Housawi, Abdulrahman ;
Garg, Amit X. .
ANNALS OF INTERNAL MEDICINE, 2006, 145 (03) :185-196
[10]  
BOURGOIGNIE JJ, 1989, KIDNEY INT, V36, pS86