LiCl regulates mitochondrial biogenesis during megakaryocyte development

被引：31
|
作者：
Undi, Ram Babu [1 ]
Gutti, Usha [2 ]
Gutti, Ravi Kumar [1 ]
机构：
[1] Univ Hyderabad, Sch Life Sci, Dept Biochem, Stem Cells & Haematol Disorders Lab, PO Gachibowli, Hyderabad 500046, Telangana, India
[2] GITAM Univ, GITAM Inst Sci, Dept Biotechnol, Visakhapatnam 530045, Andhra Pradesh, India
来源：
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2017年 / 39卷
关键词：
Megakaryocyte; Wnt signaling; Mitochondria; LiCl; MOLECULAR-MECHANISM; PLATELET COUNT; LITHIUM; CELLS; ACTIVATION; PROLIFERATION; DISEASE; MATURATION; DEPLETION; RECEPTOR;
D O I：
10.1016/j.jtemb.2016.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
JAK-STAT, PI3K-AKT and MAPK signaling pathways are involved in platelet production process. Although wnt signaling has been reported in the biogenesis of platelets, but its role in megakaryocyte development is not well studied. We used an inducible canonical wnt signaling system that utilizes LiCl (GSK-3 beta inhibitor). LiCl could activate wnt signaling pathway along with maturation of megakaryocytes. Mitochondrial staining showed an increase in mitochondrial mass upon induction with LiCl. Also, mitochondria) markers PGC-1 alpha and TFAM were up regulated with increase in mitochondrial DNA content. LiCl leads to increase in the ROS production, suggesting significance of mitochondria in megakaryocyte development. (C) 2016 Elsevier GmbH. All rights reserved.
引用
收藏
页码：193 / 201
页数：9
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