Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

被引：26
|
作者：
Jung, Yong Woo [1 ]
Lee, Hwanbum [1 ]
Kim, Jae Yeon [1 ]
Koo, Eun Jin [1 ]
Oh, Keun Sang [1 ]
Yuk, Soon Hong [1 ]
机构：
[1] Korea Univ, Coll Pharm, Sejong 339700, South Korea
来源：
CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 28期
基金：
新加坡国家研究基金会;
关键词：
Antitumor efficacy; cancer targetability; chitosan/heparin composite; core/shell nanoparticles; enhanced permeability and retention effect; layer-by-layer approach; molecular imaging agent; Pluornics; Pluronic/liposome composite nanoparticles; polyethylene glycol; protein drug; self-assembly; temperature-induced phase transition; vesicle fusion; CORE VESICLE NANOPARTICLES; TRIBLOCK COPOLYMER MELTS; INDUCED PHASE-TRANSITION; GH-DEFICIENT PATIENTS; BLOOD-BRAIN-BARRIER; GROWTH-HORMONE GH; BLOCK-COPOLYMERS; IN-VIVO; CANCER-THERAPY; AQUEOUS-SOLUTION;
D O I：
10.2174/09298673113209990036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
引用
收藏
页码：3488 / 3499
页数：12
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