Determination of zolpidem and its metabolites by chromatography-mass spectrometry

被引：6
|
作者：
Krylova, E. A. [1 ]
Kataev, S. S. [1 ]
Khomov, Yu. A. [2 ]
机构：
[1] Perm Reg Bur Forens Med Examinat, Perm 614077, Russia
[2] Perm State Pharmaceut Acad, Perm 614081, Russia
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2013年 / 68卷 / 08期
关键词：
zolpidem; metabolism; solid-phase extraction; gas chromatography; mass spectrometric detection;
D O I：
10.1134/S1061934813080066
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Conditions of the simultaneous isolation of various types of zolpidem metabolites from samples of real urine by solid-phase extraction have been optimized. Various derivatives of zolpidem hydroxy- and carboxy-metabolites were obtained; their mass-spectral and gas-chromatographic characteristics have been studied. The results ensure the reliable identification of zolpidem metabolites by gas chromatography-mass spectrometry for chemical toxicological and forensic investigations.
引用
收藏
页码：722 / 729
页数：8
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